Exploiting lignin-based nanomaterials for enhanced anticancer therapy: A comprehensive review and future direction

被引:2
|
作者
Wang, Haoyu [1 ,2 ]
Wang, Xiaoyang [2 ]
Wang, Long [1 ]
Wang, Haifan [2 ]
Zhang, Yuxing [1 ]
机构
[1] Xijing Univ, Biomed Res Ctr, Xian 710123, Shaanxi, Peoples R China
[2] Jiaotong Univ, Affiliated Hosp 2, Dept Orthoped, Xian 710004, Shaanxi, Peoples R China
关键词
Lignin; Anticancer therapy; Drug delivery; cancer treatment; Biocompatibility; Synthesis methods; PH-RESPONSIVE DELIVERY; DRUG-DELIVERY; ENGINEERED NANOPARTICLES; CHEMICAL-MODIFICATIONS; ANTIOXIDANT ACTIVITY; EFFICIENT DELIVERY; WHEAT-STRAW; SYSTEMS; FUNCTIONALIZATION; POLYMERS;
D O I
10.1016/j.ijbiomac.2024.136266
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Lignin, a renewable and abundant natural polymer, has emerged as a promising candidate for anticancer therapy due to its unique properties and biocompatibility. This review provides a comprehensive overview of recent advancements in the utilization of lignin-based nanomaterials for enhancing anticancer drug delivery and therapeutic outcomes. A detailed examination of the literature reveals several synthesis methods, including nanoprecipitation, microemulsion, and solvent exchange, which produce lignin nanoparticles with improved drug solubility and bioavailability. The anticancer mechanisms of lignin nanoparticles, such as the generation of reactive oxygen species (ROS), induction of apoptosis, and enhanced cellular uptake, are also explored. Lignin nanoparticles loaded with drugs like curcumin, doxorubicin, camptothecin, and resveratrol have demonstrated the ability to improve drug efficacy, selectively target cancer cells, overcome multidrug resistance, and minimize toxicity in both in vitro and in vivo studies. These nanoparticles have shown significant potential in suppressing tumor growth, inducing cell death through apoptotic pathways, and enhancing the synergistic effects of combination therapies, such as chemo-phototherapy. Future research directions include optimizing lignin nanoparticle formulations for clinical applications, refining targeted delivery mechanisms to cancer cells, and conducting thorough biocompatibility and toxicity assessments. Overall, this review highlights the significant progress made in utilizing lignin-based nanomaterials for cancer therapy and outlines promising areas for further exploration in this rapidly evolving field.
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页数:23
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