Preparation and characterization of large porous poly(HEMA-co-EDMA) microspheres with narrow size distribution by modified membrane emulsification method

被引：0
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作者：
Qu, Huanhuan [1 ,2 ]
Gong, Fangling [1 ]
Ma, Guanghui [1 ]
Su, Zhiguo [1 ]
机构：
[1] National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100080, China
[2] Graduate University, Chinese Academy of Sciences, Beijing 100049, China
来源：
Journal of Applied Polymer Science | 2007年 / 105卷 / 03期
关键词：
Porous poly(2-hydroxyethyl methacrylate-coethylene dimethacrylate) [p(HEMA-co-EDMA)] microspheres have important applications in chromatography. In this study; p(HEMA-co-EDMA) microspheres with controllable size were successfully prepared by modified membrane emulsification technique. The CV value of the obtained microspheres was as low as 14.4%. An oil phase mainly composed of toluene was permeated through a membrane with uniform pores into an aqueous phase to form fairly uniform seed emulsion. The secondary emulsion composed of HEMA and EDMA was prepared by a homogenizer. Then; the two emulsions were mixed together. HEMA and EDMA diffused into the aqueous phase; and then were absorbed by the seed droplets. The swollen droplets were further polymerized to prepare monodisperse porous microspheres. It was found that HEMA/EDMA ratio and toluene/monomer ratio showed a significant influence on swelling degree; diameter; and morphology of the obtained microspheres. The swelling degree of the microspheres increased with the increase of toluene/monomer ratio; whereas the average diameter increased with decrease of the ratio. Microspheres with controllable size (28-73 μm) and porosity were obtained; by varying HEMA/EDMA ratios and toluene/monomer ratios. It can be expected that the p(HEMA-co-EDMA) microspheres with controllable size and porosity will provide many advantages in their applications. © 2007 Wiley Periodicals; Inc;
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页码：1632 / 1641
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