Current innovations in mRNA vaccines for targeting multidrug-resistant ESKAPE pathogens

被引：1

作者：

Imani, Saber ^{[1
]}

Lv, Shuojie ^{[1
]}

Qian, Hongbo ^{[1
]}

Cui, Yulan ^{[1
]}

Li, Xiaoyan ^{[1
]}

Babaeizad, Ali ^{[2
]}

Wang, Qingjing ^{[1
]}

机构：

[1] Zhejiang Shuren Univ, Shulan Int Med Coll, Key Lab Artificial Organs & Computat Med Zhejiang, Key Lab Pollut Exposure & Hlth Intervent Zhejiang, Hangzhou 310015, Zhejiang, Peoples R China

[2] Semnan Univ Med Sci, Fac Med, Semnan, Iran

来源：

BIOTECHNOLOGY ADVANCES | 2025年 / 79卷

关键词：

mRNA vaccines; Multidrug-resistant; ESKAPE pathogens; Antigen selection; mRNA vaccine technology; CAPSULAR POLYSACCHARIDE VACCINE; ENTEROCOCCAL SURFACE PROTEIN; OUTER-MEMBRANE PROTEINS; III SECRETION SYSTEM; PSEUDOMONAS-AERUGINOSA; KLEBSIELLA-PNEUMONIAE; ANTIBIOTIC-RESISTANCE; MOLECULAR-DETECTION; CANDIDATE VACCINE; VIRULENCE FACTORS;

D O I：

10.1016/j.biotechadv.2024.108492

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The prevalence of multidrug-resistant (MDR) ESKAPE pathogens, including Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa, represents a critical global public health challenge. In response, mRNA vaccines offer an adaptable and scalable platform for immunotherapy against ESKAPE pathogens by encoding specific antigens that stimulate B-cell-driven antibody production and CD8+ T-cell-mediated cytotoxicity, effectively neutralizing these pathogens and combating resistance. This review examines recent advancements and ongoing challenges in the development of mRNA vaccines targeting MDR ESKAPE pathogens. We explore antigen selection, the nuances of mRNA vaccine technology, and the complex interactions between bacterial infections and antibiotic resistance. By assessing the potential efficacy of mRNA vaccines and addressing key barriers to their paraclinical implementation, this review highlights the promising function of mRNA-based immunization in combating MDR ESKAPE pathogens.

引用

页数：21

共 261 条

[91] Pseudomonas aeruginosa: An Audacious Pathogen with an Adaptable Arsenal of Virulence Factors [J].