Global small-angle scattering data analysis of inverted hexagonal phases

被引：0

作者：

Frewein, Moritz P. K. ^{[1
,2
]}

Rumetshofer, Michael ^{[3
]}

Pabst, Georg ^{[1
,2
]}

机构：

[1] University of Graz, Institute of Molecular Biosciences, Biophysics Division, NAWI Graz, Graz,8010, Austria

[2] BioTechMed Graz, Graz,8010, Austria

[3] Graz University of Technology, Institute of Theoretical Physics and Computational Physics, NAWI Graz, Graz,8010, Austria

来源：

Journal of Applied Crystallography | 2019年 / 52卷 / 02期

关键词：

A global analysis model has been developed for randomly oriented; fully hydrated; inverted hexagonal (HII) phases formed by many amphiphiles in aqueous solution; including membrane lipids. The model is based on a structure factor for hexagonally packed rods and a compositional model for the scattering length density; enabling also the analysis of positionally weakly correlated HII phases. Bayesian probability theory was used for optimization of the adjustable parameters; which allows parameter correlations to be retrieved in much more detail than standard analysis techniques and thereby enables a realistic error analysis. The model was applied to different phosphatidylethanolamines; including previously unreported HII data for diC14:0 and diC16:1 phosphatidylethanolamine. The extracted structural features include intrinsic lipid curvature; hydrocarbon chain length and area per lipid at the position of the neutral plane. © Moritz P. K. Frewein et al. 2019;

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页码：403 / 414