Structure-activity relationship of insulinomimetic activity of zinc(II) complexes with pyridine-2-sulfonic acid derivatives

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作者：
Yoshikawa, Yutaka [1 ]
Morishita, Mika [2 ]
Nishide, Midori [2 ]
Yoshikawa, Eriko U. [2 ]
Kinoshita, Isamu [4 ]
Okada, Keiji [3 ]
Kajiwara, Naemi M. [2 ]
Sakurai, Hiromu [1 ]
Kojima, Yoshitane [3 ]
机构：
[1] Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, 5 Nakauchi-cho, Yamashina-ku, Kyoto 607-8414
[2] Laboratory of Nutrition Physiology, Graduate School of Life Science, Kobe Women's University, 5 Aoyama, Higashisuma, Suma-ku, Kobe 654-8585
[3] Department of Chemistry, Graduate School of Science, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka 558-8585
[4] Department of Material Science, Graduate School of Science, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka 558-8585
来源：
Bulletin of the Chemical Society of Japan | 2007年 / 80卷 / 03期
关键词：
We prepared zinc(II) complexes with a series of monomethyl-substituted pyridine-2-sulfonic acid derivatives to clarify the relationship between the structure and insulinomimetic activity. Towards in vitro insulinomimetic activity; bis(3-methylpyridine-2-sulfonato)zinc(II) gave the best result among the zinc(II) complexes with methylpyridine-2-sulfonates. © 2007 The Chemical Society of Japan;
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Journal article (JA)
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页码：530 / 532
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