Novel N-heterocyclic carbene silver(I) complexes: Synthesis, structural characterization, antimicrobial and cytotoxicity potential studies

被引：0
作者：
Karaca, Emine Ozge [1 ]
Mizrak, Ebru [2 ]
Gurbuz, Nevin [1 ,2 ,3 ]
Cetinkaya, Erdem [4 ]
Karci, Huseyin [2 ]
Dundar, Muhammed [5 ]
Ozdemir, Ilknur [2 ,3 ]
Koc, Ahmet [6 ]
Ozdemi, Ismail [1 ]
Koko, Waleed [7 ]
Al-Hazmy, Sadeq M. [8 ]
Hamdi, Naceur [9 ]
机构：
[1] Inonu Univ Catalyst Res, Applicat Ctr, TR-44280 Malatya, Turkiye
[2] Inonu Univ Drug Applicat, Res Ctr, TR-44280 Malatya, Turkiye
[3] Inonu Univ, Fac Arts & Sci, Dept Chem, TR-44280 Malatya, Turkiye
[4] Univ Hlth Sci, Antalya Training & Res Hosp, Dept Otorhinolaryngol, TR-07100 Antalya, Turkiye
[5] Inonu Univ, Fac Arts & Sci, Dept Mol Biol & Genet, TR-44280 Malatya, Turkiye
[6] Inonu Univ, Fac Med, Dept Med Biol & Genet, TR-44280 Malatya, Turkiye
[7] Qassim Univ, Coll Sci, Dept Biol, Qasim 51452, Saudi Arabia
[8] Qassim Univ, Coll Sci, Dept Chem, Buraydah 51452, Saudi Arabia
[9] Univ Carthage, Higher Inst Environm Sci & Technol, Res Lab Environm Sci & Technol LR16ES09, Hammam Lif, Tunisia
来源：
INORGANICA CHIMICA ACTA | 2025年 / 577卷
关键词：
Catalysts; Structure analysis; Anticancer activity; Antimicrobial activity; 6-Dimethylbenzimidazole; N -Heterocyclic carbene; Silver complexes; SALTS; NHC;
D O I：
10.1016/j.ica.2024.122458
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
In this study, a new series of 1-(2-ethylhexyl)-3-(alkyl)-5,6-dimethylbenzimidazol-2-ylidene]silver(I) complexes has been synthesized and investigated their in vitro antibacterial, antifungal and anticancer properties. All molecules were characterized by 1H NMR, 13C NMR, and IR spectroscopy techniques. In vitro antimicrobial activity of the synthesized compounds investigated in this work was tested against the reference strains: Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213) and Pseudomonas aeruginosa (ATCC 27853), Candida albicans (ATCC MYA-2876) and Candida glabrata (ATCC 2001). Anticancer properties of samples were evaluated against A549, HCT116 and BEAS-2B cells lines. All silver-NHC complexes showed antibacterial activity against the tested bacterial and fungal strains.
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页数：8
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