Green Synthesis of Biocompatible Chiral Gold Nanoparticles

被引:0
作者
Fan, Yuan [1 ,2 ,3 ]
Li, Na [2 ]
Wang, Jiaolong [1 ,2 ]
Liao, Lan [1 ,2 ]
Wei, Junchao [1 ,2 ,3 ]
机构
[1] Nanchang Univ, Jiangxi Med Coll, Sch Stomatol, Nanchang 330006, Jiangxi, Peoples R China
[2] Jiangxi Prov Key Lab Oral Dis, Nanchang 330006, Peoples R China
[3] Jiangxi Prov Clin Res Ctr Oral Dis, Nanchang 330006, Peoples R China
基金
中国国家自然科学基金;
关键词
alginate; chiral; gold; nanoparticle; green synthesis; NANOMATERIALS;
D O I
10.3390/polym16233333
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Chiral gold nanoparticles (Au NPs) have been investigated widely and have shown great potential in biomedical applications, such as biosensing, combating bacterial infections and tissue regeneration. However, some stabilizers and reducing agents for the synthesis of chiral Au NPs can produce toxicity in living organisms. Therefore, it is interesting to design green methods to prepare chiral gold nanoparticles that are nontoxic, environment-friendly, and low-cost. Herein, novel biocompatible chiral Au NPs with a diameter of 54.4 +/- 14.9 nm were prepared by the in situ reduction of HAuCl4 with alginates as the green reducing agent and chiral-inducing and stabilizing agent. XPS, TGA, UV-Vis and CD analyses demonstrated that alginate-stabilized chiral Au NPs (ALG-Au NPs) were successfully prepared, while biocompatibility assessment showed that cell viability was 116.0% when the concentration of ALG-Au NPs arrived at 300 mu g/mL, which indicated that ALG-AuNPs showed excellent biocompatibility. Furthermore, the ALG-Au NPs can respond to metal ions, such as Ca2+, Cu2+, Mn2+ and so on, implying potential application for biosensing.
引用
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页数:8
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