Exploring the comorbidity mechanism of Chaihu Jia Longgu Muli Decoction in the treatment of vertigo and anxiety disorder based on network pharmacology and molecular docking

被引：0

作者：

Dong, Hanshuo ^{[1
]}

Zhang, Bin ^{[2
]}

Teng, Xin ^{[2
]}

Sun, Li ^{[1
]}

机构：

[1] Dizziness Clinic, Jilin Provincial Academy of Chinese Medicine Sciences, Jilin, Changchun, China

[2] Changchun University of Chinese Medicine, Jilin, Changchun, China

来源：

Journal of Biotech Research | 2024年 / 19卷

关键词：

The incidence of vertigo with anxiety has been increasing year by year. Vertigo with anxiety significantly affects the physical and mental health of patients and reduces their quality of life. Therefore; how to effectively treat this condition has attracted widespread attention. This study investigated the mechanism of Chaihu Jia Longgu Muli Decoction (CLMD) in treating the co-morbidities of vertigo and anxiety utilizing network pharmacology and molecular docking technology. The active ingredients and action targets of CLMD were obtained from the TCMSP; BATMAN-TCM; HERB databases. The disease targets for vertigo disease and anxiety disorder were acquired using Genecard; OMIM; and DRUGBANK databases. These data sources were integrated and analyzed to identify the key action targets for the co-treatment of heterogeneous diseases by CLMD. The network visualization and STRING mapping of the protein interaction network were performed using Cytoscape v3.8.2. Additionally; Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were conducted using Metascape platform. The molecular docking was verified using AutoDock. A total of 100 effective active ingredients were obtained from CLMD. Among these; 262 potential targets were predicted with 101 key targets being identified as exerting therapeutic effects. The notable targets included AKT1; IL6; TNF; VEGFA; IL1B; and others. The GO and KEGG databases were primarily utilized to investigate the involvement of these active ingredients and targets in various signaling pathways including 5-hydroxytryptaminergic synapses; dopaminergic neural synapses; cAMP signaling pathways; calcium signaling pathways. The molecular docking analysis revealed a strong binding affinity between the active ingredients and the crucial target molecules. Network pharmacological analysis further elucidated that CLMD exerted its therapeutic effects on the co-occurrence of vertigo and anxiety through diverse biological processes and associated signaling pathways. These findings contributed valuable insights into the underlying mechanism of CLMD in the treatment of vertigo and anxiety comorbidities. © (2024); (Bio Tech System). All rights reserved;

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页码：125 / 134

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