Dynamic Hyaluronic Acid Hydrogels for Comprehensively Regulating Inflammation, Angiogenesis, and Metabolism to Effectively Proheal Diabetic Wounds

被引：1
作者：
Chen, Yanzheng [1 ]
Wang, Qing [2 ]
Ning, Fangrui [1 ]
Du, Chang [3 ]
Chen, Mingsheng [5 ]
Feng, Chuanliang [4 ]
Dong, Chang-Ming [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Shanghai Key Lab Elect Insulat & Thermal Aging, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China
[2] Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Dept Stomatol, Shanghai 200080, Peoples R China
[3] Naval Mil Med Univ, Clin Canc Inst, Ctr Translat Med, Shanghai 200433, Peoples R China
[4] Shanghai Jiao Tong Univ, Sch Mat Sci & Engn, State Key Lab Met Matrix Composites, Shanghai 200240, Peoples R China
[5] Fudan Univ, Shanghai Publ Hlth Clin Ctr, Shanghai 201508, Peoples R China
来源：
ACS APPLIED MATERIALS & INTERFACES | 2024年 / 16卷 / 51期
基金：
中国国家自然科学基金; 上海市自然科学基金;
关键词：
polymeric hydrogel; hyaluronic acid; hydrogensulfide; wound inflammation; angiogenesis; metabolism regulation; chronic and diabetic wounds; MACROPHAGES; STRESS;
D O I：
10.1021/acsami.4c15674
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Despite the great progress of various multifunctional wound dressings, it is challenging to simultaneously achieve complete healing and functional remodeling for diabetic foot ulcers and refractory chronic wounds. Aiming to comprehensively regulate chronic inflammation, angiogenesis, and metabolism processes, herein, a novel kind of dynamic hyaluronic acid (HA) hydrogel was designed by combining boronate and coordination chemistry. Besides having injectability, self-healing, and detachment properties, dynamic HA hydrogels presented diabetic wound-responsive degradation and controllable H2S release. They could efficiently polarize M1-to-M2 polarization and regulate inflammatory cytokine secretion and multiple inflammation-related mRNA expressions through cooperative actions of reactive oxygen species elimination + H2S release + Zn2+ regulation, thus driving chronic inflammation into the proliferation and remodeling stages. Moreover, the screened lead hydrogel HTZS could regulate angiogenesis-related signaling pathways and metabolism processes to promote neovascularization and mature vessel formation, re-epithelization, high-level collagen-I deposition, and dense hair follicle regeneration, achieving complete healing and functional remodeling in diabetic wounds. Importantly, this work opens a new avenue to design dynamic biopolymer hydrogels for high-performance wound dressing and decipher the key role of multiple orchestrated regulations of inflammation-angiogenesis-metabolism on complete healing and functional remodeling in chronic and diabetic wounds.
引用
收藏
页码：70256 / 70273
页数：18
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