Lead distribution in rats following respiratory exposure to lead-contaminated soils

被引：3

作者：

Veterinary Medical Diagnostic Laboratory, University of Missouri, Columbia, MO, United States ^{[1
]}

不详 ^{[2
]}

机构：

[1] Veterinary Medical Diagnostic Laboratory, University of Missouri, Columbia, MO

[2] U.S. Army Center for Health Promotion and Preventive Medicine, Aberdeen Proving Ground, MD

来源：

Toxicol. Environ. Chem. | 2008年 / 5卷 / 971-982期

关键词：

Intratracheal instillation; Lead; Soil;

D O I：

10.1080/02772240701782173

中图分类号：

学科分类号：

摘要：

Two preliminary experiments were performed to explore the use of an intratracheal instillation technique as a cost-effective method of determining the biokinetics of lead (Pb) following respiratory exposure to Pb-contaminated soils. A novel intratracheal instillation procedure was refined and used to deliver a defined dose of Pb-contaminated soil or PbAc to the lower respiratory tract of rats. In the first experiment, rats were sacrificed at numerous time intervals post-dosing, and liver, kidney, blood, and bone tissues were collected for Pb analysis. In the second experiment, rats were dosed with Pb-contaminated soil or PbAc via intratracheal instillation or gastric gavage. All rats were sacrificed 96 h after dose administration and tissues were collected for lead analysis. Data from these experiments indicate Pb is well-absorbed following intratracheal instillation of Pb-contaminated soil, and the intratracheal instillation technique could be used as a cost effective method for exploring the biokinetics of Pb in Pb-contaminated soils following respiratory tract exposure. © 2008 Taylor & Francis.

引用

页码：971 / 982

页数：11

共 12 条

[1]

Toxicological profile for lead, (1999)

[2]

Toxicological profile for lead, (2005)

[3]

Update: Blood lead levels-United States, MMWR (Morbidity and Mortality Weekly Report), 46, 7, pp. 1991-1994, (1997)

[4]

Blood lead levels-United States, MMWR (Morbidity and Mortality Weekly Report), 54, 20, pp. 1999-2002, (2005)

[5]

Driscoll K.E., Costa D.L., Hatch G., Henderson R., Oberdorster G., Salem H., Schlesinger R.B., Intratracheal instillation as an exposure technique for the evaluation of respiratory tract toxicity: Uses and limitations, Toxicology Science, 55, pp. 24-35, (2000)

[6]

Garcia Vargas G.G., Rubio Andrade M., Del Razo L.M., Borja Aburto V., Vera Aguilar E., Cebrian M.E., Lead exposure in children living in a smelter community in region Lagunera, Mexico, Journal of Toxicology and Environmental Health A, 62, pp. 417-429, (2001)

[7]

Goyer R.A., Results of lead research: Prenatal exposure and neurological consequences, Environmental Health Perspect, 104, pp. 1050-1054, (1966)

[8]

Lanphear B.P., Roghmann K.J., Pathways of lead exposure in urban children [abstract], Environmental Resarch, 74, (1997)

[9]

Lorenzana R.M., Troast R., Mastriano M., Follansbee M.H., Diamond G.L., Lead intervention and pediatric blood lead levels at hazardous waste sites, Toxicology and Environmental Health Part A, 66, pp. 871-893, (2003)

[10]

Sabaitis C.P., Leong B.K.J., Rop D.A., Aaron C.S., Validation of intratracheal instillation as an alternative for aerosol inhalation toxicity testing, Journal of Applied Toxicology, 19, pp. 133-140, (1999)

← 1 2 →