Biodegradable and thermoresponsive micelles of triblock copolymers based on 2-(N,N-dimethylamino)ethyl methacrylate and Ε-caprolactone for controlled drug delivery

被引：0

作者：

San Miguel, Verónica ^{[1
]}

Limer, A.J. ^{[2
]}

Haddleton, D.M. ^{[2
]}

Catalina, Fernando ^{[1
]}

Peinado, Carmen ^{[1
]}

机构：

[1] Instituto de Ciencia y Tecnología de Polímeros, C.S.I.C., C/Juan de la Cierva 3, 28006 Madrid, Spain

[2] Department of Chemistry, University of Warwick, CV4 7L, Coventry, United Kingdom

来源：

European Polymer Journal | 2008年 / 44卷 / 11期

关键词：

Amphiphilic triblock copolymers; poly(2-(N; N-dimethylamino)ethyl methacrylate)x-block-poly(caprolactone)-block-poly(2-(N; N-dimethylamino)ethyl methacrylate)x; PDMAEMACo; were synthesized. Polymerization and structural features of the polymers were analyzed by different physicochemical techniques (GPC; 1H NMR and FTIR). Formation of hydrophobic domains as cores of the micelles was studied by 1H NMR and further confirmed by fluorescence. Dynamic light scattering measurements showed a monodispersed size distribution only for the copolymer with the lowest degree of polymerization; while increasing the length of PDMAEMA blocks leads to a bimodal size distribution. The micelles showed reversible dispersion/aggregation in response to temperature cycles through an outer polymer shell lower critical solution temperature (LCST) for PDMAEMA at temperatures between 54 and 87 °C. The triblock copolymer micelles were loaded with the sparingly water-soluble anticancer drug; chlorambucil; by a dialysis procedure. The drug release profile monitored by fluorescence showed that the release of chlorambucil from PDMAEMA nanoparticles is controlled by a combined degradation-diffusion mechanism. © 2008 Elsevier Ltd. All rights reserved;

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页码：3853 / 3863