A new method of synthesis of 1-cyclohexyloxy-2,2,6,6-tetramethylpipirid-4-one

被引：0
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作者：
机构：
[1] State Key Laboratory of Chemical Engineering, Department of Chemical Engineering and Biochemical Engineering, Zhejiang University
来源：
Zhou, Q.-Y. (zqyf@zju.edu.cn) | 1600年 / Zhejiang University卷 / 27期
关键词：
1-cyclohexyloxy-2,2,6,6-tetramethylpipirid-4-one; Nitroxyl radical; Sterically hindered amine; Synthesis;
D O I：
10.3969/j.issn.1003-9015.2013.02.011
中图分类号：
学科分类号：
摘要：
Sterically hindered amine shows great advantages among the various kinds of flame retardants. 1-cyclohexyloxy-2,2,6,6-tetramethylpipirid-4-one is the key intermediate for synthesizing this kind of flame retardant. In this paper, we proposed a novel method for synthesizing 1-cyclohexyloxy-2,2,6,6-tetramethylpipirid-4-one with a higher yield. First, sterically hindered nitroxyl radical was synthesized by using the existing method. Then, cyclohexane and the obtained nitroxyl radical were used to synthesize 1-cyclohexyloxy-2,2,6,6-tetramethylpipirid-4-one. Tert-butyl hydroperoxide and copper bromide were employed as the redox initiator system and tetrabutyl ammonium bromide as the phase transfer catalyst. The target product was characterized by electron-spin resonance (ESR) and electro spray ionization-mass spectroscopy (ESI-MS). The effects of metal catalyst and phase transfer catalyst on product yield were investigated. The catalytic mechanism of the reaction was also studied. The product yield using this method can reach 82%.
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页码：243 / 247
页数：4
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