Comparison of structural characteristics and anti-tumor activity of two alkali extracted peach gum arabinogalactan

被引:2
|
作者
Dai, Ke-yao [1 ]
Ding, Wen-jie [1 ]
Li, Zhen-tong [1 ]
Liu, Chao [1 ]
Ji, Hai-yu [2 ]
Liu, An-jun [1 ]
机构
[1] Tianjin Univ Sci & Technol, Coll Food Sci & Engn, Key Lab Food Nutr & Safety, Minist Educ, 29,13th St, Tianjin 300457, Peoples R China
[2] Yantai Univ, Coll Life Sci, Yantai 264005, Shandong, Peoples R China
关键词
Anti-tumor activity; Peach gum arabinogalactans; Structural characteristics; POLYSACCHARIDES;
D O I
10.1016/j.ijbiomac.2024.135407
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Two polysaccharides, PGP-90 and PGP-100 (molecular weights of 7.59 x 10(2) kDa and 10.48 x 10(2) kDa, respectively), were isolated from Peach gum using alkaline electrolyte water as an extraction solution. Structural characterization showed that PGP-90 and PGP-100 are AG-II arabinogalactans with beta-D-(1 -> 6)-Galp as the main chain and 1 -> 3 Araf and 1 -> 5 Araf branched chains at O-3 and O-4 positions. Animal experiments showed that PGP-90 and PGP-100 significantly improved immune function, enhance the proliferative capacity of lymphocytes and phagocytosis of peritoneal macrophages, and regulated the ratio of lymphocyte subpopulations in S180 tumor-bearing mice. Meanwhile, PGP-90 and PGP-100 promoted the secretion of cytokines (TNF-alpha, IFN-gamma, and IL-2) by activated macrophages and blocked apoptosis at the G1 phase, resulting in tumor suppression rates of 40.80 % and 46.30 % (100 mg/kg), respectively, with PGP-100 demonstrating stronger in vivo anti-tumor activity. The above experimental results indicate that Peach gum polysaccharides have the potential to be functional anti-tumor agents.
引用
收藏
页数:12
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