Visible-light-induced three component difluoromethylation cyclization carbo-thioesterification to CF2-Containing γ-Lactams

被引：0
|
作者：
Shao, Dan [1 ]
Yu, Tingting [1 ]
Sun, Lianglong [2 ]
Sun, Zongfei [2 ]
Zhou, Xiaorui [2 ]
Liu, Chunyang [3 ]
Chen, Xuebo [3 ]
Wang, Xin [2 ]
Sun, Kai [2 ]
机构：
[1] Jilin Univ, China Japan Union Hosp, Dept Pharm, Changchun, Jilin, Peoples R China
[2] Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China
[3] Shandong Lab Adv Mat & Green Mfg Yantai, Yantai 264000, Peoples R China
来源：
MOLECULAR CATALYSIS | 2025年 / 570卷
基金：
中国国家自然科学基金;
关键词：
Photoinduced; Difluoromethylation; Carbo-thioesterification; gamma-Lactams; Radical; COPPER-MEDIATED DIFLUOROMETHYLATION; CATALYZED AMINODIFLUOROALKYLATION; FACILE SYNTHESIS; FLUORINE; ARYL; DIFLUOROALKYLATION; INHIBITION; BROMIDES; ALKENES; ALKYNES;
D O I：
10.1016/j.mcat.2024.114685
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
A facile visible-light-induced photocatalytic cascade difluoromethylation cyclization of bromodifluoroacetamides and subsequent carbo-thioesterification is described. This protocol allows efficient access to a variety of valuable CF2-containing gamma-lactams in moderate to excellent yields under mild conditions. Detailed mechanism study suggest that a radical pathway is involved in the catalytic cycle.
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页数：7
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