In situ preparation and drug release properties of validamycin-loaded silica hollow microcapsules

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Key Lab for Nanomaterials, Beijing University of Chemical Technology, Beijing 100029, China [1 ]
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Guocheng Gongcheng Xuebao | 2008年 / 3卷 / 595-598期
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摘要：
Validamycin-loaded silica hollow microspheres were prepared by in situ hydrolysis of tetraethyl orthosilicate (TEOS) in Water-Oil (W/O) emulsions. The microspheres were characterized by SEM, XRD, FT-IR and particle size distribution. The results indicated that the drug-loaded microspheres had an amorphous hollow spherical structure with the diameters of 7.5~15 μm. The amount of validamycin entrapped in the microspheres was about 31.9%(ω). Sustained-releasing studies showed that the release time was about 240 min and more than 90% of the loaded drug in the microspheres was delivered, indicating good sustained release behavior of the drug-loaded microspheres.
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