Engineering target-responsive hydrogels based on aptamer-target interactions

被引：0
|
作者：
Yang, Huanghao [1 ,2 ]
Liu, Haipeng [1 ]
Kang, Huaizhi [1 ]
Tan, Weihong [1 ]
机构：
[1] Department of Chemistry, McKnight Brian Institute, University of Florida, Gainesville, FL 32611-7200, United States
[2] First Institute of Oceanography, SOA, Qingdao, 266061, China
来源：
Journal of the American Chemical Society | 2008年 / 130卷 / 20期
关键词：
In this communication; we report a simple; but highly adaptable; method of constructing selective target-responsive hydrogels using DNA aptamers. The simplicity of the design is accomplished by using linear polymer chains as the hydrogel backbone and a DNA aptamer as the cross-linker. In this design; competitive binding of target to the aptamer causes the decrease of cross-linking density and; hence; dissolution of the hydrogel. The adaptability of this strategy for therapeutic applications was demonstrated using two different types of targets; small molecules and proteins. Our results indicated that this molecular engineering provides a highly selective and controllable release system whereby efficient release of therapeutic agents can occur at specific environments in which the target biomarker is found. Copyright © 2008 American Chemical Society;
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摘要：
Journal article (JA)
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页码：6320 / 6321
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