Engineering target-responsive hydrogels based on aptamer-target interactions

被引：0
|
作者：
Yang, Huanghao [1 ,2 ]
Liu, Haipeng [1 ]
Kang, Huaizhi [1 ]
Tan, Weihong [1 ]
机构：
[1] Department of Chemistry, McKnight Brian Institute, University of Florida, Gainesville, FL 32611-7200, United States
[2] First Institute of Oceanography, SOA, Qingdao, 266061, China
来源：
Journal of the American Chemical Society | 2008年 / 130卷 / 20期
关键词：
In this communication; we report a simple; but highly adaptable; method of constructing selective target-responsive hydrogels using DNA aptamers. The simplicity of the design is accomplished by using linear polymer chains as the hydrogel backbone and a DNA aptamer as the cross-linker. In this design; competitive binding of target to the aptamer causes the decrease of cross-linking density and; hence; dissolution of the hydrogel. The adaptability of this strategy for therapeutic applications was demonstrated using two different types of targets; small molecules and proteins. Our results indicated that this molecular engineering provides a highly selective and controllable release system whereby efficient release of therapeutic agents can occur at specific environments in which the target biomarker is found. Copyright © 2008 American Chemical Society;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Journal article (JA)
引用
收藏
页码：6320 / 6321
相关论文
共 50 条
  • [1] Engineering target-responsive hydrogels based on aptamer - Target interactions
    Yang, Huanghao
    Liu, Haipeng
    Kang, Huaizhi
    Tan, Weihong
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (20) : 6320 - +
  • [2] Biophysical Characterization of Aptamer-Target Interactions
    Plach, Maximilian
    Schubert, Thomas
    APTAMERS IN BIOTECHNOLOGY, 2020, 174 : 1 - 15
  • [3] A colorimetric nanosensor based on a selective target-responsive aptamer kissing complex
    Goux, E.
    Dausse, E.
    Guieu, V.
    Azema, L.
    Durand, G.
    Henry, M.
    Choisnard, L.
    Toulme, J. -J.
    Ravelet, C.
    Peyrin, E.
    NANOSCALE, 2017, 9 (12) : 4048 - 4052
  • [4] AptaDB: a comprehensive database integrating aptamer-target interactions
    Chen, Long
    Yu, Zhuohang
    Wu, Zengrui
    Zhou, Moran
    Wang, Yimeng
    Yu, Xinxin
    Li, Weihua
    Liu, Guixia
    Tang, Yun
    RNA, 2024, 30 (03) : 189 - 199
  • [5] Mapping the gaps in chemical analysis for the characterisation of aptamer-target interactions
    Daems, Elise
    Moro, Giulia
    Campos, Rui
    De Wael, Karolien
    TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 2021, 142
  • [6] In vitro selection of a trans aptamer complex for target-responsive fluorescence activation
    Park, Soyeon V.
    Kang, Byunghwa
    Lee, Minjong
    Yoo, Hyebin
    Jo, Hyesung
    Woo, Sungwook
    Oh, Seung Soo
    ANALYTICA CHIMICA ACTA, 2024, 1301
  • [7] A target-responsive electrochemical aptamer switch (TREAS) for reagentless detection of nanomolar ATP
    Zuo, Xiaolei
    Song, Shiping
    Zhang, Jiong
    Pan, Dun
    Wang, Lihua
    Fan, Chunhai
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (05) : 1042 - 1043
  • [8] Artificial Intelligence in Aptamer-Target Binding Prediction
    Chen, Zihao
    Hu, Long
    Zhang, Bao-Ting
    Lu, Aiping
    Wang, Yaofeng
    Yu, Yuanyuan
    Zhang, Ge
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (07)
  • [9] A General Chemiluminescence Strategy for Measuring Aptamer-Target Binding and Target Concentration
    Li, Shiyuan
    Chen, Duyu
    Zhou, Qingtong
    Wang, Wei
    Gao, Lingfeng
    Jiang, Jie
    Liang, Haojun
    Liu, Yangzhong
    Liang, Gaolin
    Cui, Hua
    ANALYTICAL CHEMISTRY, 2014, 86 (11) : 5559 - 5566
  • [10] Target-responsive aptamer release from manganese dioxide nanosheets for electrochemical sensing of cocaine with target recycling amplification
    Chen, Zongbao
    Lu, Minghua
    TALANTA, 2016, 160 : 444 - 448
12345