Efficacy of silver nanoparticle-modified bullfrog skin as an antimicrobial wound dressing

被引：0

作者：

Zanoni Souto, Carlos Augusto ^{[1
]}

Gomes de Souza, Fernando ^{[1
,2
,10
]}

Pal, Kaushik ^{[3
]}

Teixeira de Seixas Filho, José ^{[4
]}

Toma, Helena Keiko ^{[5
]}

Asthana, Nidhi ^{[6
,7
]}

Khan, Azmat Ali ^{[8
]}

Fatima, Sabiha ^{[9
]}

机构：

[1] Instituto de Macromoléculas Professora Eloisa Mano, Centro de Tecnologia-Cidade Universitária, Universidade Federal de Rio de Janeiro, Rio de Janeiro, Brazil

[2] Programa de Engenharia da Nanotecnologia, COPPE, Centro de Tecnologia-Cidade Universitária, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

[3] University Centre for Research and Development (UCRD), Department of Physics, Chandigarh University, Gharuan, Punjab, Mohali,140413, India

[4] LaBios, Centro de Tecnologia-Cidade Universitária, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

[5] LACMAC, Faculdade de Farmácia, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil

[6] Department of Physics, Graphic Era (Deemed to be) University, Uttarakhand, Dehradun, India

[7] Department of Physics, Babasaheb Bhimrao Ambedkar University, U. P., Lucknow, India

[8] Pharmaceutical Biotechnology Laboratory, Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh,11451, Saudi Arabia

[9] Department of Clinical Laboratory Science, College of Applied Medical Sciences, King Saud University, Riyadh,11433, Saudi Arabia

[10] Florida International University, 10555 West Flagler St EC3900, Miami,FL,33174, United States

来源：

Journal of Molecular Structure | 2025年 / 1321卷

关键词：

Metal nanoparticles;

D O I：

10.1016/j.molstruc.2024.139961

中图分类号：

学科分类号：

摘要：

This research explores the synthesis of silver nanoparticles and their incorporation into bullfrog skin for potential use as a wound dressing. The study addresses the need for wound dressings that exhibit biocompatibility, low cytotoxicity, superior biodegradability, and antimicrobial activity. Silver nanoparticles were synthesized using silver nitrate and sodium citrate solutions and integrated into bullfrog skin at varying concentrations (0%, 0.5%, 1%, and 1.5%). The modified and unmodified bullfrog skin samples were characterized using dynamic light scattering(DLS), X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM), and Energy Dispersive Spectroscopy (EDS). Antimicrobial analyses were conducted to assess the efficacy of the modified skin against common pathogens, including Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, and Candida albicans. The results demonstrated that samples containing 1% and 1.5% silver nanoparticles exhibited significant inhibitory effects on all tested microorganisms. This indicates that these concentrations are optimal for antimicrobial activity, suggesting the potential of silver nanoparticle-modified bullfrog skin as an innovative and effective wound dressing material. © 2024 Elsevier B.V.

引用

共 2 条

[1] Physicochemical properties and antimicrobial activity of biocompatible carboxymethylcellulose-silver nanoparticle hybrids for wound dressing and epidermal repair
Capanema, Nadia S. V.
Mansur, Alexandra A. P.
Carvalho, Sandhra M.
Mansur, Lorena L.
Ramos, Carolina P.
Lage, Andrey P.
Mansur, Herman S.
JOURNAL OF APPLIED POLYMER SCIENCE, 2018, 135 (06)
[2] Silver-nanoparticle-Incorporated composite nanofibers for potential wound-dressing applications
Gopinath, P. (pgopifnt@iitr.ernet.in), 1600, John Wiley and Sons Inc (132):

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