Image-guided patient-specific prediction of interstitial fluid flow and drug transport in solid tumors

Tumor fluid dynamics and drug delivery simulations in solid tumors are highly relevant topics in clinical oncology. The current study introduces a novel method combining computational fluid dynamics (CFD) modeling, quantitative magnetic resonance imaging (MRI; including dynamic contrast-enhanced (DCE) MRI and diffusion-weighted (DW) MRI), and a novel ex-vivo protocol to generate patient-specific models of solid tumors in four patients with peritoneal metastases. DCE-MRI data were analyzed using the extended Tofts model to estimate the spatial distribution of tumor capillary permeability using the Ktrans parameter. DW-MRI data analysis provided a 3D representation of drug diffusivity, and DW-MRI coupled to an ex-vivo measurement protocol informed the spatial heterogeneity of the hydraulic conductivity of tumor tissue. The patient-specific data were subsequently incorporated into a computational fluid dynamics (CFD) model to simulate individualized tumor perfusion and drug transport maps. The results on interstitial fluid flow demonstrated noticeable heterogeneity of interstitial fluid pressure and velocity within the tumor, along with heterogeneous drug penetration profiles among different tumors, even with a similar drug administration regimen.