In vitro evaluation of electrospun gelatin-bioactive glass hybrid scaffolds for bone regeneration

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[1] Gao, Chunxia
[2] Gao, Qiang
[3] Li, Yadong
[4] Rahaman, Mohamed N.
[5] Teramoto, Akira
[6] Abe, Koji
来源：
Gao, C. (s09t155@shinshu-u.ac.jp) | 1600年 / John Wiley and Sons Inc卷 / 127期
关键词：
Organic-inorganic hybrid materials; composed of phases that interact on a nanoscale and a microstructure that mimics the extracellular matrix; can potentially provide attractive scaffolds for bone regeneration. In the present study; hybrid scaffolds of gelatin and bioactive glass (BG) with a fibrous microstructure were prepared by a combined sol-gel and electrospinning technique and evaluated in vitro. Structural and chemical analyses showed that the fibers consisted of gelatin and BG that were covalently linked by 3- glycidoxypropyltrimethoxysilane to form a homogeneous phase. Immersion of the gelatin-BG hybrid scaffolds in a simulated body fluid (SBF) at 37°C resulted in the formation of a hydroxyapatite (HA)-like material on the surface of the fibers within 12 h; showing the bioactivity of the scaffolds. After 5 days in SBF; the surface of the hybrid scaffolds was completely covered with an HA-like layer. The gelatin-BG hybrid scaffolds had a tensile strength of 4.3 ± 1.2 MPa and an elongation to failure of 168 ± 14%; compared to values of 0.5 ± 0.2 MPa and 63 ± 2% for gelatin scaffolds with a similar microstructure. The hybrid scaffolds supported the proliferation of osteoblastic MC3T3-E1 cells; alkaline phosphatase activity; and mineralization during in vitro culture; showing their biocompatibility. The results indicate that these gelatin-BG hybrid scaffolds prepared by a combination of sol-gel processing and electrospinning have potential for application in bone regeneration. © 2012 Wiley Periodicals; Inc; J; Appl; Polym; Sci; 2013 Copyright © 2012 Wiley Periodicals;
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