Evaluation of retention and release processes of two antibiotics from the biocompatible core-shell microparticles

被引：0
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作者：
Vasiliu, Silvia [1 ]
Popa, Marcel [2 ]
Luca, Cornelia [1 ]
机构：
[1] Petru Poni Institute of Macromolecular Chemistry, Aleea Grigore Ghica Voda, 41A, 700487 Iasi, Romania
[2] Gh.Asachi Technical University, Faculty of Chemical Engineering, Department of Macromolecules, Bd. D. Mangeron, 71A, 700050 Iasi, Romania
来源：
European Polymer Journal | 2008年 / 44卷 / 11期
关键词：
By dropwise addition of a chitosan solution into different non-solvent; such as: 1 N and 2 N NaOH as well as 1 N NaOH: C2H5OH mixture (2:1; v/v) at temperature of 25 °C and 50 °C under stirring; the spherical pure chitosan microparticles were performed. As solvents for chitosan was used 0.1 N acetic acid or 0.1 N HCl. The immersion of the pure chitosan microparticles in hyaluronan solution led to complex microparticles; namely chitosan microparticles covered by a hyaluronan layer. For all the microparticles performed the behaviours in the retention process of two antibiotics: chloramphenicol succinate sodium salt and cefotaxime sodium salt were analyzed. Also; the study shows the release behaviour of cefotaxime sodium salt by the microparticles loaded with this drug. Among the microparticles performed a type of complex microparticles can be considered a suitable drug delivery system for cefotaxime. These microparticles were performed by dropwise addition of chitosan solution in 0.1 N acetic acid into the 1 N NaOH: C2H5OH (2:1; v/v) non-solvent at 20 °C for 3 h; followed by their washing up to alkalinity loss and the immersion in hyaluronan solution of 10 g/L concentration for 24 h. © 2008 Elsevier Ltd. All rights reserved;
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页码：3894 / 3898
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