Synthesis of magnetic resonance/fluorescence bimodal molecular imaging probe based on gadolinium-doped carbon quantum dots by microwave-hydrothermal method

被引：0

作者：

School of Materials Science and Engineering, Southwest University of Science and Technology, Mianyang ^{[1
]}

621010, China

不详 ^{[2
]}

622750, China

机构：

[1] School of Materials Science and Engineering, Southwest University of Science and Technology, Mianyang

[2] Beichuan Tiannuo Photoelectric Material Co., Ltd., Mianyang

来源：

Faguang Xuebao | / 12卷 / 1383-1389期

关键词：

Carbon quantum dots; Fluorescence; Gadolinium ions; Magnetic resonance; Molecular imaging probe;

D O I：

10.3788/fgxb20153612.1383

中图分类号：

学科分类号：

摘要：

Using gadopentetic acid monomeglumine (GdPM) as precursor to provide simultaneously the carbon source and gadolinium (3+) source, gadolinium-doped carbon quantum dots (Gd3+/CQDs-MH) with uniformly small size were obtained at a mild condition by microwave hydrothermal method which can realize a molecular level mixing. When GdPM was pyrolyzed under 250℃ for 45 min, Gd3+/CQDs-MH with high quantum yield (QY) and longitudinal relaxation rate (r1) were obtained. The contradiction between quantum yield and the relaxation properties has been well balanced, which is very difficult to avoid using traditional heating method. The prepared Gd3+/CQDs-MH with an average diameter of about 1.0 nm show little cell toxicity and exhibit a high photoluminescence quantum yield of 11.0%, as well as a high r1 value of 4 545.3 mmol-1·L·s-1 ([Gd3+]=0.01 mmol·L-1) with the doping mass fraction of gadolinium (3+) of 16.9%. Therefore, the Gd3+/CQDs-MH show big possibility for application in magnetic resonance/fluorescence bimodal molecular imaging. © 2015, SCIENCE PRESS. All right reserved.

引用

页码：1383 / 1389

页数：6

共 12 条

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