Numerical detection simulation of microchip electrophoresis in a pure pressure-driven laminar flow

被引：0
|
作者：
Huang, Chung-Chien [1 ]
Hung, Chen-I [1 ]
机构：
[1] Department of Mechanical Engineering, National Cheng-Hung University, Tainan 701, Taiwan
来源：
Journal of the Chinese Society of Mechanical Engineers, Transactions of the Chinese Institute of Engineers, Series C/Chung-Kuo Chi Hsueh Kung Ch'eng Hsuebo Pao | 2011年 / 32卷 / 03期
关键词：
Electrophoresis - Charged particles - Microchannels - Signal detection - Microprocessor chips - Diffusion;
D O I：
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中图分类号：
学科分类号：
摘要：
This study presents a numerical detection simulation of microchip electrophoresis in a straight microchannel through the pressure-driven laminar flow. The simulation is used to calculate charged particle movement caused by the transport mechanism of convection, diffusion, and electrophoretic migration for imitating the electrophoresis detection apparatus to obtain the electropherogram. The simulated detection signals from four detectors at different positions in the microchannel are used to study the effect of time. The simulation results indicate that the effects of diffusion and the velocity profile caused by pressure gradient reduce the amplitude of detection signals with time and form the different distribution of particle patterns. The magnitude of detection area also effects the strength of detection signals.
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页码：209 / 218
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