Corneal epithelial thickness map in long-term soft contact lenses wearers

被引：33
作者：
机构：
[1] Department of Ophthalmology, Eye, Ear, Nose, and Throat Hospital, Shanghai Medical School, Fudan University, Shanghai
[2] Department of Immunology, Shanghai Medical School, Fudan University, Shanghai
[3] School of Life Sciences, Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen
[4] Cornea Division, Jules Stein Eye Institute, University of California, Los Angeles, 90001, CA
[5] Department of Ophthalmology Eye, Ear, Nose, and Throat Hospital, Shanghai Medical School, Fudan University, 83 Fenyang Rd, Shanghai
来源：
| 1600年 / Lippincott Williams and Wilkins卷 / 91期
基金：
中国国家自然科学基金;
关键词：
Corneal epithelial thickness; Long-term wear; Optical coherence tomography; Soft contact lenses;
D O I：
10.1097/OPX.0000000000000410
中图分类号：
学科分类号：
摘要：
Purpose. To map the corneal epithelial thickness in vivo with Fourier-domain optical coherence tomography in long-term soft contact lens (SCL) wearers. Methods. This is a cross-sectional observational study. Forty eyes from 40 normal subjects who had never worn SCL and 40 eyes from 40 SCL wearers who had worn lenses for more than 2 years were enrolled. Corneal epithelium over the entire cornea was topographically imaged using a novel optical coherence tomography system. An epithelial thickness map was automatically generated. Epithelial thicknesses of the central 2-mm, paracentral 2- to 5-mm(P1), and midperipheral 5- to 6-mm (P2) zones were obtained. In addition, the epithelial map variability in P1 and P2 zones, including maximum - minimum (MAX - MIN), map SD, and coefficient of variation (CV), was measured and analyzed. Results. The average epithelial thickness of the central, P1, and P2 zones was 54.4 ± 1.1 μm, 53.2 ± 2.2 μm, and 52.3 ± 2.0 μm, respectively, in normal eyes and 49.2 ± 1.9 μm, 48.8 ± 2.2 μm, and 48.7 ± 2.8 μm, respectively, in eyes wearing SCL. Compared with normal control subjects, eyes with long-term SCL had significantly thinner epithelial thickness in all three zones (p > 0.05). However, there was no difference in MAX - MIN, SD, and CV of P1 and P2 zones between two groups. In both groups, there was significant difference in the epithelial thickness among different sectors in the paracentral and midperipheral zones.Conclusions. There is a decrease in epithelial thickness in subjects who wear SCL long term. Clinicians should take note of the nonuniformity of the paracentral and midperipheral corneal epithelium thicknesses. This method may be useful for detecting early changes in corneal epithelial thickness caused by long-term SCL wear. Copyright © American Academy of Optometry.
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页码：1455 / 1461
页数：6
相关论文
共 19 条
  • [1] Nichols J.J., Contact lenses 2008, Contact Lens Spectrum, 24, pp. 24-28, (2009)
  • [2] Holden B.A., Sweeney D.F., Vannas A., Nilsson K.T., Efron N., Effects of long-term extended contact lens wear on the human cornea, Invest Ophthalmol Vis Sci, 26, pp. 489-501, (1985)
  • [3] Yamamoto K., Ladage P.M., Ren D.H., Li L., Petroll W.M., Jester J.V., Cavanagh H.D., Effect of eyelid closure and overnight contact lens wear on viability of surface epithelial cells in rabbit cornea, Cornea, 21, pp. 85-90, (2002)
  • [4] Stapleton F., Stretton S., Papas E., Skotnitsky C., Sweeney D.F., Silicone hydrogel contact lenses and the ocular surface, Ocul Surf, 4, pp. 24-43, (2006)
  • [5] Perez J.G., Meijome J.M., Jalbert I., Sweeney D.F., Erickson P., Corneal epithelial thinning profile induced by long-term wear of hydrogel lenses, Cornea, 22, pp. 304-307, (2003)
  • [6] Haque S., Jones L., Simpson T., Thickness mapping of the cornea and epithelium using optical coherence tomography, Optom Vis Sci, 85, pp. E963-E976, (2008)
  • [7] Li Y., Tan O., Brass R., Weiss J.L., Huang D., Corneal epithelial thickness mapping by Fourier-domain optical coherence tomography in normal and keratoconic eyes, Ophthalmology, 119, pp. 2425-2433, (2012)
  • [8] Kanellopoulos A.J., Asimellis G., In vivo 3-dimensional corneal epithelial thickness mapping as an indicator of dry eye: Preliminary clinical assessment, Am J Ophthalmol, 157, pp. 63-68, (2014)
  • [9] Qian Y., Xue F., Huang J., Qu X., Zhou X., Lanen-Wanek D.V., Pachymetry map of corneal epithelium in children wearing orthokeratology contact lenses, Curr Eye Res, 39, pp. 263-270, (2014)
  • [10] Shen M., Xu Z., Yang C., Leng L., Liu J., Chen Q., Wang J., Lu F., Agreement of corneal epithelial profiles produced by automated segmentation of SD-OCTimages having different optical resolutions, Eye Contact Lens, 40, pp. 99-105, (2014)
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