Copper-based biomimetic nanozymes with multi-enzyme activity for phosphate detection

被引：1
作者：
Fu, Zhendong [1 ]
Zhang, Tongjia [1 ]
Chen, Cong [1 ]
Wang, Xiaoyu [1 ]
Wang, Liping [1 ]
机构：
[1] Jilin Univ, Sch Life Sci, Natl Engn Lab AIDS Vaccine, Key Lab Mol Enzymol & Engn,Minist Educ, Changchun 130012, Peoples R China
来源：
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2025年 / 329卷
基金：
中国国家自然科学基金;
关键词：
Nanozyme; Bio-mimic design; Phosphate detection; Laccase; Carbonic anhydrase; PEROXIDASE-LIKE ACTIVITY; COMPLEXES;
D O I：
10.1016/j.saa.2024.125599
中图分类号：
O433 [光谱学];
学科分类号：
0703 ; 070302 ;
摘要：
Nanozymes are nanoparticles with enzymatic activity, which are widely used in environmental and antibacterial research. Herein, we designed and synthesized novel amorphous nanozyme Cu-Im NPs with multiple enzyme- mimicking activities. Cu-Im NPs have the same active sites as natural laccase. In addition, the active center is similar to that of carbonic hydrolase, replacing the zinc ions with copper ions. Meanwhile, Cu-Im NPs also possess peroxidase-like activity. We reveal the multi-enzyme catalytic mechanisms of Cu-Im NPs. Notably, phosphate inhibits the laccase-like and peroxidase-like activities of Cu-Im NPs while activating their hydrolase activity. Based on these findings, we have developed a sensitive and selective method for detecting phosphate anions.
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页数：11
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