Features of the interaction of 5-[4′-(6"-aminopurin-2"-yl) phenyl]-10,15,20-tri(N-methylpyridin-3′-yl)-porphyrin with nucleic acids

被引:0
|
作者
Lebedeva, Natalia Sh. [1 ]
Yurina, Elena S. [1 ]
Kiselev, Aleksey N. [1 ,2 ]
Lebedev, Mikhail A. [1 ,2 ]
Syrbu, Sergey A. [1 ]
机构
[1] Russian Acad Sci, GA Krestov Inst Solut Chem, Ivanovo, Russia
[2] Ivanovo State Univ Chem & Technol, Ivanovo, Russia
基金
俄罗斯科学基金会;
关键词
Porphyrins; Nucleic acids; Intercalate; CATIONIC PORPHYRINS; METAL-COMPLEXES; DNA; BINDING; DYNAMICS; LIGAND;
D O I
10.1016/j.ijbiomac.2024.139411
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Directed synthesis of novel water-soluble asymmetric porphyrins containing in a molecule three cationic fragments and residues of adenine (PorAD) was performed, using metal-complex catalysis method. The interaction of the synthesized porphyrin with the oligonucleotides poly[d(AT)2] and poly[d(GC)2] and double-stranded deoxyribonucleic acid of the calf thymus (ctDNA) was studied by means of spectral and hydrodynamic methods. It was established that PorAD intercalated not only into GC-enriched regions, but also into AT regions. It was revealed that a distinctive feature of PorAD complexes with nucleic acids was a weak shielding from water molecules, and it implies significant disturbances in the conformation of the nucleic acid; the disturbances being especially pronounced for poly[d(AT)2].
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页数:7
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