Effects of ionizing radiation on the expression of 1α-hydroxylase in renal tubular epithelial cells

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Department of Bone Metabolism, Institute of Radiation Medicine, Fudan University, Shanghai 200032, China [1 ]
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Fushe Yanjiu yu Fushe Gongyi Xuebao | 2006年 / 1卷 / 34-38期
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The work was to study in vitro the effects of ionizing radiations on the expression of 1α-hydroxylase in renal tubular epithelial cells, which were exposed to 3 Gy, 5 Gy and 10 Gy by 137Cs γ-rays. By using real-time Q-PCR technology and transmission electron microscopy (TEM), changes in the 1α-hydroxylase mRNA level and the mitochondria infrastructure after the irradiation were compared with the control (0 Gy) group. An obvious decrease in the 1α-hydroxylase mRNA expression was found after the 3 Gy irradiation, and the decreasing rate increased with the irradiation dose. The TEM results also showed that with the irradiated cells the mitochondria swelled obviously, the electron density decreased, and the cristae arrangement broke and disordered.
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