Accidental overdose of travoprost

被引：4
作者：
机构：
[1] Pacific University College of Optometry, Forest Grove, OR
[2] Pacific University College of Optometry, 2043 College Way, Forest Grove, 97116, OR
来源：
| 1600年 / Lippincott Williams and Wilkins卷 / 91期
关键词：
Adverse reactions; Bimatoprost; Drug-related side effects; Prostaglandin analogs; Travoprost;
D O I：
10.1097/OPX.0000000000000408
中图分类号：
学科分类号：
摘要：
Purpose. To report systemic symptoms after an overdose of travoprost. Case Report. We report a patient who, instead of artificial tears, inadvertently used travoprost every 15 minutes for 7 hours after LASIK (laser-assisted in situ keratomileusis) surgery. She experienced abrupt, severe abdominal cramps and sudden, severe menstrual bleeding, which subsided quickly upon discontinuation of the drug. Conclusions. Because of the few systemic adverse effects, prostaglandin analogs are widely used for the treatment of glaucoma. Travoprost should be taken once daily; therefore, overdose is extremely uncommon. Systemic prostaglandins have been found to be mediators of uterine activity and are used to induce labor and terminate pregnancies. The high dose of this topical medication, as well as the compromised cornea, makes this case unique. The unusual circumstances observed in this case greatly expand our knowledge regarding the potential adverse effects of travoprost. Copyright © American Academy of Optometry.
引用
收藏
页码：e298 / e300
页数：2
相关论文
共 16 条
  • [11] O'Brien W.F., The role of prostaglandins in labor and delivery, Clin Perinatol, 22, pp. 973-984, (1995)
  • [12] Pluchon M., Winer N., Misoprostol in case of termination of pregnancy in the second and third trimesters. Trials, J Gynecol Obstet Biol Reprod (Paris), 43, pp. 162-168, (2014)
  • [13] Tsalacopoulos G., Bloch B., Rush J.M., Missed abortion treated with intramuscular 15-(S)-15-methyl-prostaglandin F2 alpha, S Afr Med J, 61, pp. 828-830, (1982)
  • [14] Natrajan P.K., Tzingounis V.A., Cervical dilation with prostaglandin F2 alpha for first trimester abortion, South Med J, 79, pp. 830-831, (1986)
  • [15] De Santis M., Lucchese A., Carducci B., Cavaliere A.F., De Santis L., Merola A., Straface G., Caruso A., Latanoprost exposure in pregnancy, Am J Ophthalmol, 138, pp. 305-306, (2004)
  • [16] Lee Y.C., Abdominal cramp as an adverse effect of travoprost, Am J Ophthalmol, 139, pp. 202-203, (2005)
12