Dual-responsive nanoparticles for enhanced drug delivery in breast Cancer chemotherapy

被引：3

作者：

Ren, Yuxin ^{[1
,2
]}

Li, Peishan ^{[1
,2
]}

Xie, Ying ^{[1
,2
]}

Xu, Jiarui ^{[1
,2
]}

Luo, Qian ^{[1
,2
]}

Chen, Ming ^{[1
,2
]}

Liu, Rui ^{[1
,2
]}

Feng, Hexuan ^{[1
,2
]}

Chen, Yuling ^{[1
,2
]}

Liu, Yixuan ^{[1
,2
]}

Bao, Chunjie ^{[1
,2
]}

Duan, Jialun ^{[1
,2
]}

Li, Jianwei ^{[1
,2
,3
,4
]}

Lu, Wanliang ^{[1
,2
]}

机构：

[1] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing Key Lab Mol Pharmaceut & New Drug Delivery, Beijing, Peoples R China

[2] Peking Univ, Sch Pharmaceut Sci, Beijing, Peoples R China

[3] Changzhi Med Coll, Sch Pharm, Changzhi 046000, Peoples R China

[4] Beijing Zhendong Guangming Pharmaceut Res Inst Co, Beijing 100080, Peoples R China

来源：

JOURNAL OF CONTROLLED RELEASE | 2025年 / 377卷

基金：

中国国家自然科学基金;

关键词：

Dual-responsive nanoparticle; pH responsiveness; Glutathione responsiveness; Deep penetration; Chemotherapy; NANOMEDICINE; MICELLES; CELLS;

D O I：

10.1016/j.jconrel.2024.11.026

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Drug delivery efficiency often affects chemotherapy outcome due to dense collagen barrier in tumor environment. Here, we report a nanoparticle capable of pH and glutathione dual-responsive drug delivery to enhance the efficacy of breast cancer chemotherapy. Maleiminated polyethylene glycol and polylactide block copolymer were synthesized as a core material, doxorubicin was encapsulated into the nanoparticle by self-assembly. Thiocollagenase and maleimide were connected on the nanoparticle surface by click chemistry, and further coated with chondroitin sulfate as a protective layer to form dual-responsive doxorubicin nanoparticle. The results showed that the nanoparticle had the ability to penetrate deep tumor tissue, to target on CD44 of cancer cell, and to release doxorubicin in cancer cell in response to pH and glutathione signals, demonstrating superior anticancer efficacy in breast cancer-bearing mice. In conclusion, the dual-responsive nanoparticle could be used as a drug carrier to enhance drug delivery in breast cancer chemotherapy.

引用

页码：146 / 161

页数：16

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