Targeted nanoprobe for magnetic resonance imaging-guided enhanced antitumor via synergetic photothermal/immunotherapy

被引:0
作者
Chen, Ruoyu [1 ,3 ]
Lin, Xiaowen [1 ]
Tao, Pengyu [1 ]
Wan, Yuxin [1 ]
Wen, Xin [1 ,2 ]
Shi, Jiaying [1 ]
Li, Jie [1 ]
Huang, Chao [4 ]
Zhou, Jiayi [5 ]
Xie, Nan [1 ]
Han, Cuiping [1 ,2 ]
机构
[1] Xuzhou Med Univ, Sch Med Imaging, Xuzhou 221004, Peoples R China
[2] Xuzhou Med Univ, Affiliated Hosp, Dept Radiol, Xuzhou 221004, Peoples R China
[3] Soochow Univ, Affiliated Hosp 1, Dept Radiol, Suzhou 215006, Peoples R China
[4] Xuzhou Med Univ, Canc Inst, Clin Med Coll 1, Xuzhou, Jiangsu, Peoples R China
[5] Xuzhou Med Univ, Sch Pharm, Xuzhou 221004, Peoples R China
关键词
MnO2; nanosheets; Photothermal therapy; Immunotherapy; Magnetic resonance imaging; Breast cancer; CANCER-IMMUNOTHERAPY; TUMOR;
D O I
10.1016/j.jcis.2024.08.205
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Synergistic photothermal/immunotherapy has garnered significant attention for its potential to enhance tumor therapeutic outcomes. However, the fabrication of an intelligent system with a simple composition that simultaneously exerts photothermal/immunotherapy effect and imaging guidance function still remains a challenge. Herein, a glutathione (GSH)-responsive theranostic nanoprobe, named HA-MnO2/ICG, was elaborately constructed by loading photothermal agent (PTA) indocyanine green (ICG) onto the surface of hyaluronic acid (HA)- modified manganese dioxide nanosheets (HA-MnO2) for magnetic resonance (MR) imaging-guided synergetic photothermal/immuno-enhanced therapy. In this strategy, HA-MnO2 nanosheets were triggered by the endogenous GSH in tumor microenvironment to generate Mn2+ for MR imaging, where the longitudinal relaxation rate of HA-MnO2/ICG was up to 14.97 mM(-1)s(-1) (similar to 24 times than that found in a natural environment), demonstrating excellent intratumoral MR imaging. Moreover, the HA-MnO2/ICG nanoprobe demonstrates remarkable photothermal therapy (PTT) efficacy, generating sufficient heat to induce immunogenic cell death (ICD) within tumor cells. Meanwhile the released Mn2+ ions from the nanosheets function as potent immune adjuvants, amplifying the immune response against cancer. In vivo experiments validated that HA-MnO2/ICG-mediated PTT was highly effective in eradicating primary tumors, while simultaneously enhancing immunogenicity to prevent the growth of distal metastasis. This hybrid HA-MnO2/ICG nanoprobe opened new avenues in the design of MR imaging-monitored PTT/immuno-enhanced synergistic therapy for advanced cancer.
引用
收藏
页码:937 / 949
页数:13
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