Adaptive dMLC gating radiotherapy based on real-time motion tracking

被引：0
|
作者：
Zhou, Zhengdong [1 ]
Chen, Yuanhua [1 ]
Yu, Zili [1 ]
机构：
[1] Department of Nuclear Science and Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing
来源：
Dongnan Daxue Xuebao (Ziran Kexue Ban)/Journal of Southeast University (Natural Science Edition) | 2014年 / 44卷 / 05期
关键词：
Adaptive dynamic multi-leaf collimator (dMLC) gating; Radiotherapy; Respiratory motion; Tumor motion compensation;
D O I：
10.3969/j.issn.1001-0505.2014.05.008
中图分类号：
学科分类号：
摘要：
A novel adaptive dynamic multi-leaf collimator (dMLC) gating radiotherapy is proposed. The leaf opening/closing of dMLC is controlled by the real-time tracking of the tumor and organ at risk (OAR). The treatment beam turns on only when there is no overlapping between OAR and tumor in beam's eye view (BEV). The experimental results of the retrospective simulations of four synchronous tracking data show that the tumor and OAR motion patterns and their relative positions are the dominant influential factors. For different tumor-OAR motion patterns, the duty cycle can be up to 96.71% and yet may be only 14.12%. The increase of the transverse distance in BEV can improve the duty cycle and reduce the irradiated OAR volume; whereas, the increase of the tumor external boundary exhibits an opposite influence. This proposed technique can provide good OAR protection, especially for cases with low duty cycle, in which as high as 77.71% direct irradiation to OAR can be spared.
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页码：917 / 923
页数：6
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  • [1] Haas M.L., Advances in radiation therapy for lung cancer , 24, 1, pp. 34-40, (2008)
  • [2] Butler L.E., Forster K.M., Stevens C.W., Et al., Dosimetric benefits of respiratory gating: a preliminary study , 5, 1, pp. 16-24, (2004)
  • [3] Guckenberger M., Krieger T., Richter A., Et al., Potential of image-guidance, gating and real-time tracking to improve accuracy in pulmonary stereotactic body radiotherapy , Radiotherapy and Oncology, 91, 3, pp. 288-295, (2008)
  • [4] Wong J.W., Sharpe M.B., Jaffray D.A., Et al., The use of active breathing control (ABC) to reduce margin for breathing motion , International Journal of Radiation Oncology, Biology, Physics, 44, 4, pp. 911-919, (1999)
  • [5] Nissen H.D., Appelt A.L., Improved heart, lung and target dose with deep inspiration breath hold in a large clinical series of breast cancer patients , Radiotherapy and Oncology, 106, 1, pp. 28-32, (2013)
  • [6] Bouilhol G., Ayadi M., Rit S., Et al., Is abdominal compression useful in lung stereotactic body radiation therapy? A 4DCT and dosimetric lobe-dependent study , 29, 4, pp. 333-340, (2013)
  • [7] Korreman S.S., Pedersen A.N., NOttrup T.J., Et al., Breathing adapted radiotherapy for breast cancer: Comparison of free breathing gating with the breath-hold technique , Radiotherapy and Oncology, 76, 3, pp. 311-318, (2005)
  • [8] Pepin E.W., Wu H., Shirato H., Dynamic gating window for compensation of baseline shift in respiratory-gated radiation therapy , 38, 4, pp. 1912-1918, (2011)
  • [9] Hau E., Rains M., Pham T., Et al., Potential benefits and pitfalls of respiratory-gated radiotherapy in the treatment of thoracic malignancy , Asia-Pacific Journal of Clinical Oncology, 10, 2, pp. e13-e20, (2014)
  • [10] Pepin E.W., Wu H., Shirato H., Use of dMLC for implementation of dynamic respiratory-gated radiation therapy , 40, 10, (2013)
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