The origin of Sonochemistry is an acoustic cavitation process in the liquid phase ; those are the nucleation, growth and violent collapse. Here, instantaneous hot-spot with high temperature and pressure is generated in the local region by the bubble collapse. The authors have proposed to apply the sonochemistry into a heavy fuel oil mixed with a lower boiling point fuel for reformulation of the heavy fuel oil and reported the advantage of the mixed fuel. Thus, the several experimental results relating to the fuel reformulation in the previous studies. Then, it is necessary to clarify a theoretical analysis for reformulation process based on cavitation dynamics. Therefore, the authors develop an energy modeling on the cavitation bubble collapse have process for reformulation of two-component fuel by use of Sonochemistry. And it is confirmed that reformulation efficiency of mixed fuel is higher than that of the pure fuel case.