Condenser is the key equipment in the nuclear power secondary loop system. Its structure size and performance parameters are important factors affecting the thermal efficiency and reasonable arrangement of nuclear power plant. According to the structure and heat transfer process of marine nuclear power condenser, the mathematical model of condenser is established in this paper, including thermodynamic calculation, structure design, strength calculation, resistance calculation, weight calculation, volume calculation, and thermal performance evaluation. Based on sensitivity analysis, the influence trend and degree of thermal and structural parameters on weight, volume, and entropy generation of condenser are discussed. The optimal design of condenser, aiming at the weight, volume, and entropy generation minimization while satisfying the structure and performance constraints, has been carried out with the multi-objective particle swarm optimization algorithm, the Pareto optimal solution set and Pareto front are obtained. The optimization results show that compared with the original design scheme, the condenser weight can be optimized up to 9.566%, the volume can be optimized up to 23.779%, and the entropy generation can be optimized up to 3.666%. The optimization results also prove the feasibility of the optimization design method from a theoretical point of view, which can provide reference for the practical engineering design and operation of marine nuclear power condenser. © 2022 by Begell House, Inc.