Chitosan: A versatile bio-platform for breast cancer theranostics

被引：0

作者：

Madamsetty, Vijay Sagar ^{[1
]}

Tavakol, Shima ^{[2
]}

Moghassemi, Saeid ^{[3
]}

Dadashzadeh, Arezoo ^{[3
]}

Schneible, John D. ^{[4
]}

Fatemi, Iman ^{[5
]}

Shirvani, Abdolsamad ^{[6
]}

Zarrabi, Ali ^{[7
]}

Azedi, Fereshteh ^{[2
,8
]}

Dehshahri, Ali ^{[9
]}

Aghaei Afshar, Abbas ^{[5
]}

Aghaabbasi, Kian ^{[10
]}

Pardakhty, Abbas ^{[11
]}

Mohammadinejad, Reza ^{[5
]}

Kesharwani, Prashant ^{[12
]}

机构：

[1] Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Jacksonville,FL,32224, United States

[2] Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran,1449614525, Iran

[3] Pôle de Recherche en Gynécologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium

[4] NC State University, Department of Chemical and Biomolecular Engineering, 911 Partners Way, Raleigh,27695, United States

[5] Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran

[6] Department of Biotechnology, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran

[7] Department of Biomedical Engineering, Faculty of Engineering and Natural Sciences, Istinye University, Istanbul,34485, Turkey

[8] Department of Neuroscience, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran,1449614535, Iran

[9] Pharmaceutical Sciences Research center, Shiraz University of Medical Sciences, Shiraz, Iran

[10] Department of Biotechnology, University of Guilan, University Campus 2, Khalij Fars Highway 5th km of Ghazvin Road, Rasht, Iran

[11] Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman,7616911319, Iran

[12] Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi,110062, India

来源：

Journal of Controlled Release | 2022年 / 341卷

关键词：

Biodegradable polymers - Diseases - Chemotherapy - Controlled drug delivery - Biomarkers - Targeted drug delivery - Biocompatibility - Drug interactions - Diagnosis;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Breast cancer is considered one of the utmost neoplastic diseases globally, with a high death rate of patients. Over the last decades, many approaches have been studied to early diagnose and treat it, such as chemotherapy, hormone therapy, immunotherapy, and MRI and biomarker tests; do not show the optimal efficacy. These existing approaches are accompanied by severe side effects, thus recognizing these challenges, a great effort has been done to find out the new remedies for breast cancer. Main finding: Nanotechnology opened a new horizon to the treatment of breast cancer. Many nanoparticulate platforms for the diagnosis of involved biomarkers and delivering antineoplastic drugs are under either clinical trials or just approved by the Food and Drug Administration (FDA). It is well known that natural phytochemicals are successfully useful to treat breast cancer because these natural compounds are safer, available, cheaper, and have less toxic effects. Chitosan is a biocompatible and biodegradable polymer. Further, it has outstanding features, like chemical functional groups that can easily modify our interest with an exceptional choice of promising applications. Abundant studies were directed to assess the chitosan derivative-based nanoformulation's abilities in delivering varieties of drugs. However, the role of chitosan in diagnostics and theranostics not be obligated. The present servey will discuss the application of chitosan as an anticancer drug carrier such as tamoxifen, doxorubicin, paclitaxel, docetaxel, etc. and also, its role as a theranostics (i.e. photo-responsive and thermo-responsive) moieties. The therapeutic and theranostic potential of chitosan in cancer is promising and it seems that to have a good potential to get to the clinic. © 2021 Elsevier B.V.

引用

页码：733 / 752