Preparation and structure identification of inclusion complex of florfenicol with hydroxypropyl-β-cyclodextrin

被引：0
|
作者：
Chen, Jianping [1 ]
Zhao, Ling [1 ]
Su, Jianyu [1 ]
Hu, Songqing [1 ]
Li, Lin [1 ]
机构：
[1] College of Light Industry and Food Sciences, South China University of Technology
来源：
Yingyong Jichu yu Gongcheng Kexue Xuebao/Journal of Basic Science and Engineering | 2013年 / 21卷 / 01期
关键词：
Florfenicol; Hydroxypropyl-β-cyclodextrin; Including mechanism; Inclusion complex; Structure identification;
D O I：
10.3969/j.issn.1005-0930.2013.01.007
中图分类号：
学科分类号：
摘要：
To preparate the inclusion complex of florfenicol with hydroxypropy-β-cyclodextrin by ultrasonic method, and identify the structure of inclusion complex by the methods of Differential Scanning Caborimetry (DSC), Fourier infrared spectrum (FTR) and X-ray powder diffractometry (XRD). The interaction and mechanism of complex between host and guestwere discussed by Chem3D program. The preparation conditions were as follows: ratio of FF and HP-β-CD was 2.5:1 (mol/mol), ultrasound temperature was 60°C, ultrasound time for 5 h. The yield of inclusion complex was 82.82% and the inclusion ratio of inclusion complex was 91.88% under the optimum conditions. At the same time, the formation of inclusion complex was proofed by DSC, FTR and XRD. The inclusion complex was formed by the hydrogen bond between FF and HP-β-CD according Chem 3D and FTR.
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页码：63 / 70
页数：7
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