Biomacromolecular hydrogel scaffolds from microfluidics for cancer therapy: A review

被引：2

作者：

Hao, Siyu ^{[1
]}

Shi, Linlin ^{[1
]}

Li, Jiayi ^{[1
]}

Shi, Jiaming ^{[1
]}

Kuang, Gaizhen ^{[2
]}

Liang, Gaofeng ^{[1
]}

Gao, Shegan ^{[1
]}

机构：

[1] Henan Univ Sci & Technol, Canc Hosp,Affiliated Hosp 1,Coll Clin Med, Henan Key Lab Microbiome & Esophageal Canc Prevent, Coll Basic Med & Forens Med,Henan Key Lab Canc Epi, Luoyang 471003, Peoples R China

[2] Wenzhou Med Univ, Affiliated Hosp 1, Dept Internal Med Oncol, Wenzhou 325035, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2024年 / 282卷

基金：

中国国家自然科学基金;

关键词：

Microfluidic; Biological macromolecules; Hydrogel scaffold; Cancer therapy; Tissue repair; HYALURONIC-ACID; TUMOR; TISSUE; MICROPARTICLES; FABRICATION; NANOCARRIERS; MICROFIBERS; MICROGELS; INSIGHT; FIBERS;

D O I：

10.1016/j.ijbiomac.2024.136738

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Traditional cancer treatment is confronted with the problem of limited therapeutic effect, tissue defects, and lack of drug screening. Hydrogel scaffolds from biological macromolecules based on microfluidic technology are a promising candidate, which can mimic tumor microenvironments to screen personalized drugs, promote the regeneration of healthy tissues, and deliver drugs for enhanced localized antitumor treatment. This review summarizes the latest research on the composition of biomacromolecular hydrogel scaffolds, the architecture of hydrogel scaffolds from microfluidic technology, and their application in cancer therapy, including anti-tumor drug screening, anti-tumor treatment, and anti-tumor treatment and tissue repair. In addition, the potential breakthroughs of this innovative platform in the clinical transformation of cancer therapy are further discussed. The insights revealed in this review are intended to guide the utilization of microfluidic technology-based biomacromolecular hydrogel scaffolds in cancer therapy.

引用

页数：21

共 161 条

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