Coordination-induced electrochemiluminescence of Zr-based metal-organic frameworks combined with an energy resonance transfer for sensitive analysis of acetamidine

被引：0

作者：

Ru, Zhuangzhuang ^{[1
]}

Zhang, Nuo ^{[1
]}

Jia, Yue ^{[1
]}

Han, Yujie ^{[1
]}

Ren, Xiang ^{[1
]}

Ma, Hongmin ^{[1
]}

Kuang, Xuan ^{[1
]}

Li, Faying ^{[1
]}

Wu, Tingting ^{[1
]}

Wang, Shoufeng ^{[1
]}

Lee, Jin Yong ^{[1
,2
]}

Wei, Qin ^{[1
]}

机构：

[1] Univ Jinan, Univ Shandong,Sch Chem & Chem Engn, Collaborat Innovat Ctr Green Chem Mfg & Accurate D, Key Lab Chem Sensing & Anal, Jinan 250022, Peoples R China

[2] Sungkyunkwan Univ, Dept Chem, Suwon 16419, South Korea

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 2025年 / 426卷

基金：

中国博士后科学基金;

关键词：

Coordination-induced; electrochemiluminescence; Zr-MOFs; Electrochemiluminescence resonance energy; transfer; Acetamidine detection;

D O I：

10.1016/j.snb.2024.137098

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The development of a simple and accurate method for the detection of acetamidine (ACE) is vital for food and environmental safety. Herein, combined with electrochemiluminescence resonance energy transfer (ECL-RET) and DNA cyclic reaction signal amplification, a highly sensitive electrochemiluminescence (ECL) sensor was fabricated for detecting ACE using Zr-TBAPy-MOFs (Zr-MOFs) as the emitters, which possessed coordination- induced electrochemiluminescence (CIECL) properties. The rigid structure of Zr-MOFs restricted intramolecular motion (RIM), inhibiting non-radiative transitions and significantly enhancing ECL efficiency compared with monomers and aggregates of 1,3,6,8- tetrakis (p-benzoic acid) pyrene (H4TBAPy). In the presence of the target ACE, the aptamer (Apt) dissociated from double-stranded DNA (Apt/S) and triggered a cascade of DNA reactions. This led to the immobilization of a double-strand labeled by tetramethylrhodamine (TAMRA) onto the electrode, facilitating ECL-RET and subsequent quenching the ECL signal. Observably, as ACE concentration increased, a linear decrease in ECL signal was observed within the detection range of 0.05 ng/mL to 100.0 ng/mL, and an impressive detection limit was 6.0 pg/mL. Our developed biosensor presented a novel approach for successful implementation of ECL-RET in ACE detection.

引用

页数：9