A discussion covers the Nopco Paper Technology Company advanced sticky control cationic polymeric system that modifies the surface of hydrophobic sticky particles, inhibiting their capability to deposit and bind to fibers in paper manufacturing and finished paper products. The problematic of sticky deposits in paper machine deposits and in finished paper is of increasing significance to the paper manufacturer. These problems lead to production disturbances and influence the quality of the finished products and production costs. The Nopco development of new polymer systems and the use of modern measurement methods are a decisive step forward in the fight against interfering foreign adhesive substances. The Nopco FlowCytometry is an on-site measurement method with which the potential to form deposits of sticky materials in a paper machine can be determined. This measurement method in the laboratory permits testing the effectiveness of chemical additives to control stickies. The discussion topics include introduction; flow cytometry; use of a new additive; practical use (case examples of packaging paper, newsprint, and tissue paper); and summary. The use of Nopcosperse ENA 2025 deposits inhibitor and fixing agent has been successful in the fight against stickies on different types of paper. Its dual operating mechanisms reduce the amount of deposits and the number of adhesive particles in the system. With the simultaneous use of the FlowCytometry as test method for the evaluation of a paper machine system, for the selection of suitable additives to combat stickies, and for the test control, Nopco has made available an effective treatment concept in the fight against stickies. In a paper plant that uses 100% secondary fibers to manufacture packaging paper, adhesive black deposits occur on the doctor blades contaminating the finished product with stickies leading to heightened customer returns. To clean the doctor blades required 1 hr per day. After Nopcosperse ENA 2025 was added at 1.5 kg/tonne pulp by a static mixer after the ENA 2025 was diluted with water at 1:50, deposits dropped by 80%. The 20% that remained were less adhesive than before and easy to remove. A paper plant produces about 250,000 tonnes/yr of newsprint from deinked paper (DIP). Adhesive deposits led to black flecks and voids in the paper. Nopcosperse ENA 2025 was then added to the feed at 1.5 kg/tonne DIP after dilution of the Nopcosperse at 1:50 before dosing,. This reduced the voids by 60% and black flecks by 30% and improved machine cleanliness. In a tissue plant of about 40,000 tonnes/yr DIP stickies led to voids and tears such that Nopcosperse ENA 2025 was added at 1.0 kg/tonne DIP after diluting with fresh water at 1:25, reducing voids and flecks and reducing cleaning time of wire and felts by 50%.