Synthesis and biological evaluation of 1, 2, 3-triazole incorporated pyrrole derivatives as anticancer agents

被引：0

作者：

Nalla, Somaiah ^{[1
]}

Aravind, S. ^{[2
]}

Annam, Sri Charitha ^{[3
]}

Padmavathi, K. V. ^{[4
]}

Syed, Tasqeeruddin ^{[5
]}

Subbarao, Mannam ^{[1
]}

机构：

[1] Acharya Nagarjuna Univ, Dept Chem, Guntur, Andhra Pradesh, India

[2] Osmania Univ, Univ Coll Sci, Dept Chem, Hyderabad, Telangana, India

[3] VNR Vignana Jyothi Inst Engn & Technol, Dept Humanities & Sci, Hyderabad, Telangana, India

[4] TRR Govt Degree Coll, SPSR Nellore, Kandukur, Andhra Pradesh, India

[5] King Khalid Univ, Coll Pharm, Dept Pharmaceut Chem, Abha, Saudi Arabia

来源：

SYNTHETIC COMMUNICATIONS | 2024年 / 54卷 / 21期

关键词：

1,2,3-Triazole; anticancer activity; carboxyamidotriazole; darolutamide; pyrrole; INHIBITORY-ACTIVITY; IN-VITRO; SCAFFOLD; DOCKING; SAR;

D O I：

10.1080/00397911.2024.2408605

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new series of 1,2,3-triazole skeleton incorporated pyrrole derivatives (11a-j) were developed and their chemical structures were confirmed by analytical data. Further, the anticancer profile of these newly derived compounds 11a-j was assessed against four types of human cancer cell lines such as human breast cancer (MCF-7), lung cancer (A549), colon cancer (Colo-205) and ovarian cancer (A2780) by employing of the MTT method and was compared with etoposide used as a positive control. Most of the examined derivatives displayed moderate to good activity compared with the positive control. Among them, five compounds 11a, 11b, 11c, 11d, and 11e showed more potent activity. Particularly, compound 11a showed superior activity.

引用

页码：1828 / 1841

页数：14

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