Room temperature dithiocarbamation of 2-tetralones with elemental sulfur and isothiocyanates S8/R-N=C=S: atom-efficient access to 4-hydroxythiazolidine-2-thiones

被引：0
作者：
Nguyen, Le Anh [1 ,2 ]
Ngo, Quoc Anh [1 ]
Retailleau, Pascal [3 ]
Nguyen, Thanh Binh [3 ]
机构：
[1] Institute of Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi
[2] Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi
[3] Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Université Paris-Sud, Université Paris-Saclay, 1, av de la Terrasse, Gif-sur-Yvette
来源：
Chemical Communications | 2024年 / 60卷 / 92期
关键词：
Compendex;
D O I：
10.1039/d4cc05053c
中图分类号：
学科分类号：
摘要：
2-Tetralones were found to undergo dithiocarbamation with elemental sulfur and isothiocyanates S8/R-N=C=S in the presence of N-methylpiperidine as a base catalyst under solvent-free conditions. The reaction could proceed quickly at room temperature to provide convenient access to substituted 4-hydroxythiazolidine-2-thiones with complete atom efficiency. The adducts could be easily dehydrated in neat TFA to give thiazole-2-thiones. © 2024 The Royal Society of Chemistry.
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页码：13586 / 13589
页数：3
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