Antibiotics Stress Response of Bacteria as Mechanism of Development of Drug Resistance

被引：0
作者：
Sharma R. [1 ]
Thakur A. [1 ]
Saini A. [2 ]
Giri S.K. [1 ]
Kumar A. [3 ]
Priya K. [4 ]
Singh G. [1 ,5 ]
机构：
[1] Department of Biotechnology, School of Basic and Applied Sciences, Maharaja Agrasen University, Baddi, Himachal Pradesh, Solan
[2] Department of Microbiology, School of Basic and Applied Sciences, Maharaja Agrasen University, Baddi, Himachal Pradesh, Solan
[3] Centre for Medical Biotechnology, Maharshi Dayanand University, Haryana, Rohtak
[4] Department of Life Sciences, SBSR, Sharda University, UP, Greater Noida
[5] Centre of Excellence for Nanotechnology, Maharaja Agrasen University, Baddi, Himachal Pradesh, Solan
来源：
ACS Symposium Series | 2023年 / 1434卷
关键词：
Bacteria - Drug therapy - Physiological models;
D O I：
10.1021/bk-2023-1434.ch002
中图分类号：
R96 [药理学]; R3 [基础医学]; R4 [临床医学];
学科分类号：
1001 ; 1002 ; 100602 ; 100706 ;
摘要：
Microbes encounter a myriad of stressors such as antibiotics and host response in the natural environment. These stressors activate different types of regulated adaptive responses which not only defend from stress but also integrate changes in the bacterial cells that will change their susceptibility against that particular stress. Exposure to stress conditions effects the sensitivity to stressors by utilizing their stress response mechanism to either speed up the recruitment of resistance determinants or advance physiological changes that involve antimicrobial action. Thus, the better understanding of stress response mechanisms against antibiotics can lead to the development of specific antibioticswith high efficacy and efficiency. This will further help to reduce the antibiotics resistance development. This chapter will try to cover the response mechanisms of bacteria against the stress induced by antibiotics. © 2023 American Chemical Society. All rights reserved.
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页码：23 / 42
页数：19
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