Ni-Catalyzed Asymmetric Reductive Arylation of α-Substituted Imides

被引：8

作者：

Chen, Li-Ming ^{[1
]}

Shin, Chungkeun ^{[1
]}

Delano, Travis J. ^{[1
]}

Carretero-Cerdan, Alba ^{[1
,2
]}

Gheibi, Golsa ^{[1
]}

Reisman, Sarah E. ^{[1
]}

机构：

[1] CALTECH, Div Chem & Chem Engn, Warren & Katharine Schlinger Lab Chem & Chem Engn, Pasadena, CA 91125 USA

[2] KTH Royal Inst Technol, CBH Sch, Div Theoret Chem & Biol, S-10044 Stockholm, Sweden

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2024年 / 146卷 / 43期

基金：

瑞典研究理事会;

关键词：

OXIDATIVE ADDITION; DERIVATIVES; THALIDOMIDE; MECHANISM; ELECTROPHILES; COMPLEXES; NICKEL;

D O I：

10.1021/jacs.4c09327

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

alpha-Aryl imides are common structural motifs in bioactive molecules and proteolysis-targeting chimeras designed for targeted protein degradation. An asymmetric Ni-catalyzed reductive cross-coupling of imide electrophiles and (hetero)aryl halides has been developed to synthesize enantioenriched alpha-arylglutarimides from simple starting materials. Judicious selection of electrophile pairs allows for coupling of both electron-rich and electron-deficient (hetero)aryl halides in good yields and enantioselectivities.

引用

页码：29523 / 29530

页数：8

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