Dietary exposure assessment to macrolide antimicrobial residues through infant formulas marketed in Brazil

被引:0
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作者
Pereira, Bianca Figueiredo de Mendonça [1 ,2 ]
Pereira, Mararlene Ulberg [1 ,2 ]
Ferreira, Rosana Gomes [1 ,2 ]
Spisso, Bernardete Ferraz [1 ,2 ]
机构
[1] Instituto Nacional de Controle de Qualidade em Saúde, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil
[2] (INCQS/FIOCRUZ), Rio de Janeiro, Brazil
来源
Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment | 2021年 / 38卷 / 10期
关键词
Health risks - Microorganisms - Food microbiology - Nutrition - Food safety - Veterinary medicine;
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摘要
Macrolides are critically important antimicrobials for both human and animal health and should be prioritized in risk assessments, as inappropriate use may result in antimicrobial resistance. The antimicrobials erythromycin, oleandomycin, spiramycin, tilmicosin and tylosin were analysed in infant formula samples by HPLC-MS/MS using a validated analytical method based on a modified QuEChERS extraction. The results of the occurrence study were employed to perform a dietary exposure assessment of infants to residues. In a total of 30 analysed samples, 73% contained spiramycin residues and 27%, tilmicosin residues. Calculated daily intakes ranged from 1.47 × 10−6 to 2.71 × 10−4 mg kg−1 body weight considering all analytes, representing 0.01–0.59% of acceptable daily intakes. The results of the dietary exposure assessment were all below acceptable daily intakes, indicating low potential health concerns. However, according to Brazilian regulations, infant formulas containing residues of one or more of the investigated analytes were deemed as non-compliant. © 2021 Taylor & Francis Group, LLC.
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页码:1672 / 1688
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