Brønsted acid-mediated thiazole synthesis from sulfoxonium ylides

被引：0
作者：
Smy, Joe L. [1 ]
Ifill, Roxanne [1 ]
Hassell-Hart, Storm [1 ]
机构：
[1] Univ Sussex, Sch Life Sci, Dept Chem, Brighton BN1 9QJ, England
来源：
CHEMICAL COMMUNICATIONS | 2024年 / 60卷 / 85期
关键词：
INSERTION; ROUTE;
D O I：
10.1039/d4cc03905j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A Br & oslash;nsted acid-mediated insertion of thioureas/thioamides into sulfoxonium ylides to synthesise 40 thiazoles (34-95% yields) under mild, metal-free conditions is described. This process is scalable, substrate-tolerant (including both alpha-substituted and heterocyclic ylides/groups) and was successfully applied to the late-stage functionalisation of the complex chemical probe molecule (+)-JQ1. A Br & oslash;nsted acid-mediated insertion of thioureas/thioamides into sulfoxonium ylides to synthesise 40 thiazoles (34-95% yields) under mild, metal-free conditions is described.
引用
收藏
页码：12401 / 12404
页数：4
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