Clinical Trial on the Effect of Ripened Pu-erh Tea on Improving Abnormal Glucose and Lipid Metabolism

被引：0

作者：

Sun Y. ^{[1
,2
]}

Li Y. ^{[3
]}

Wang L. ^{[1
,2
]}

Hou C. ^{[1
,2
]}

Hao B. ^{[4
]}

Li S. ^{[4
]}

Sun T. ^{[5
]}

Qi J. ^{[4
]}

Zhong L. ^{[3
]}

Du Q. ^{[3
]}

Xu W. ^{[6
]}

Chen Z. ^{[7
]}

Tian B. ^{[3
,8
]}

Li H. ^{[3
,8
]}

Ying J. ^{[1
,2
]}

Chen Y. ^{[3
]}

Wei Z. ^{[5
]}

机构：

[1] Nutrition and Health Research Institute, COFCO Ltd., Beijing

[2] Beijing Key Laboratory of Nutrition & Health and Food Safety, Beijing

[3] Endocrinology Department of The Second Affiliated Hospital, School of Medicine, The Chinese University of Hong Kong, Shenzhen & Longgang District People’s Hospital of Shenzhen, Shenzhen

[4] China Tea Technology (Beijing) Co. Ltd., Beijing

[5] China Tea (Yunnan) Co. Ltd., Kunming

[6] Medical Imaging Department of The Second Affiliated Hospital, School of Medicine, The Chinese University of Hong Kong, Shenzhen & Longgang District People’s Hospital of Shenzhen, Shenzhen

[7] Health Education Department of The Second Affiliated Hospital, School of Medicine, The Chinese University of Hong Kong, Shenzhen & Longgang District People’s Hospital of Shenzhen, Shenzhen

[8] Affiliated Hospital of Guangdong Medical University, Zhanjiang

来源：

Shipin Kexue/Food Science | 2024年 / 45卷 / 12期

关键词：

bile acids; glucose and lipid metabolism; gut microbiota; ripened Pu-erh tea;

D O I：

10.7506/spkx1002-6630-20230929-261

中图分类号：

学科分类号：

摘要：

This study explored the effect of commercial ripened Pu-erh tea (Y562, China Tea (Yunnan) Industry Co. Ltd.) on improving the health of populations with abnormal glucose and lipid metabolism. Qualified volunteers were recruited for nutritional epidemiological and clinical intervention studies. The volunteers were asked to drink the tea for three months. Their body composition (body mass, body mass index (BMI), body fat ratio and visceral fat), body circumferences (waist circumference, hip circumference and neck circumference), glucose metabolism-related indicators (fasting blood glucose, insulin, C-peptide, glycosylated hemoglobin), lipid metabolism-related indicators (total cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, apolipoprotein A1 and B), blood uric acid levels, liver fat contents, and gut microbiota were tested and compared before and after drinking the tea to explore its health benefits. The results showed that after drinking Y562 without any change in diet or exercise for three months, the body mass, BMI, body circumferences, blood lipids (high-density lipoprotein cholesterol, apolipoprotein A1 and B), and liver fat contents of the volunteers were significantly improved (P < 0.05). Blood glucose (fasting blood glucose, insulin, C-peptide, insulin resistance, and glycosylated hemoglobin), triglyceride, and uric acid levels were also improved, but without any statistical significance (P > 0.05). Moreover, the gut microbiota was improved, showing increased uniformity. The relative abundance of Lactobacillus, Clostridium, Akkermansia muciniphila, Clostridium screenens and Streptococcus thermophilus was increased, while that of Streptococcus, Lactococcus, Bacteroides, Bifidobacterium and Paraacteroides distasonis was decreased. This study suggests that ripened Pu-erh tea Y562 has the potential to help reduce the body mass, improve the body shape, reduce blood glucose and lipids, and alleviate non-alcoholic fatty liver disease (NAFLD). The underlying mechanism may be related to the regulation of the intestinal microecology and the bile acid pathways by Pu-erh tea. © 2024 Chinese Chamber of Commerce. All rights reserved.

引用

页码：144 / 156

页数：12

共 18 条

[1]

FANG J, YU C H, LI X J, Et al., Gut dysbiosis in nonalcoholic fatty liver disease: pathogenesis, diagnosis, and therapeutic implications, Frontiers in Cellular and Infection Microbiology, 12, (2022)

[2]

DINH T C, THI PHUONG T N, MINH L B, Et al., The effects of green tea on lipid metabolism and its potential applications for obesity and related metabolic disorders: an existing update, Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 13, 2, pp. 1667-1673, (2019)

[3]

LIN Y, SHI D F, SU B, Et al., The effect of green tea supplementation on obesity: a systematic review and dose-response meta-analysis of randomized controlled trials, Phytotherapy Research, 34, 10, pp. 2459-2470, (2020)

[4]

BAHORUN T, LUXIMON-RAMMA A, NEERGHEEN-BHUJUN V S, Et al., The effect of black tea on risk factors of cardiovascular disease in a normal population, Preventive Medicine, 54, pp. S98-S102, (2012)

[5]

TANG G Y, XU Y, ZHANG C, Et al., Green tea and epigallocatechin gallate (EGCG) for the management of nonalcoholic fatty liver diseases (NAFLD): insights into the role of oxidative stress and antioxidant mechanism, Antioxidants, 10, 7, (2021)

[6]

ZHOU J, HO C T, LONG P P, Et al., Preventive efficiency of green tea and its components on nonalcoholic fatty liver disease, Journal of Agricultural and Food Chemistry, 67, 19, pp. 5306-5317, (2019)

[7]

YI D Q, TAN X R, ZHAO Z G, Et al., Reduced risk of dyslipidaemia with oolong tea consumption: a population-based study in southern China, The British Journal of Nutrition, 111, 8, pp. 1421-1429, (2014)

[8]

DARDASHTI POUR E, YAGHOBIAN F, DEHGHAN F, Et al., Forecast of ameliorating effect of dietary flavonol consumption in white tea with or without aerobic training on type 2 diabetes (T2D) in females, Clinical Nutrition ESPEN, 45, pp. 134-140, (2021)

[9]

WANG S, QIU Y, GAN R Y, Et al., Chemical constituents and biological properties of Pu-erh tea, Food Research International, 154, (2022)

[10]

pp. 93-96, (2016)

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