Different emotional states have different impacts on the emotional system. To mitigate these impacts, the emotional system will maintain the stability of the system through various adjustment methods, such as emotional self-regulation. However, there is no hardware circuit to realize the regulation of the emotional system in different emotional states. In this article, based on the brain emotion theory of the limbic system, a memristor-based emotion regulation circuit is proposed. The circuit is composed of the thalamus module, sensory cortex module, amygdala module, and orbitofrontal cortex module. It can not only produce corresponding emotions according to different stimuli but also output and regulate the current emotional state. The function of emotion generation and emotion output is realized through the thalamus module, sensory cortex module, and amygdala module. Emotional self-regulation, emotional generalization, mood disorder and mood disorder regulation are realized through the combined action of the amygdala module and the orbitofrontal cortex module. Finally, the emotion regulation circuit composed of the memristor is applied to the fault robot monitoring, which provides a reference for the bionic intelligent robot in the actual industrial application scenario.