Nationwide human biomonitoring strategy in Korea: Prioritization of novel contaminants using GC/TOF-MS with suspect and non-target screening

被引：2

作者：

Mok, Sori ^{[1
]}

Lee, Sunggyu ^{[1
]}

Lee, Nahyun ^{[2
]}

Kim, Sungkyoon ^{[2
]}

Choi, Kyungho ^{[2
]}

Park, Jeongim ^{[3
]}

Kho, Younglim ^{[4
]}

Moon, Hyo-Bang ^{[1
]}

机构：

[1] Department of Marine Science and Convergence Technology, College of Science and Convergence Technology, Hanyang University, Ansan

[2] Graduate School of Public Health, Seoul National University, Seoul

[3] Department of Environmental Health Sciences, Soonchunhyang University, Asan

[4] Department of Health, Environment & Safety, Eulji University, Gyeonggi-do, Seongnam

来源：

Chemosphere | 2024年 / 369卷

关键词：

Emerging contaminants; Human biomonitoring; Plasticizers; Prioritization; TOF;

D O I：

10.1016/j.chemosphere.2024.143814

中图分类号：

学科分类号：

摘要：

According to global regulations on hazardous chemicals, numerous alternatives have been manufactured and used in various consumer products. Suspect and non-target analyses are advanced analytical techniques used for identifying novel contaminants. In the present study, suspect and non-target analytical approaches using a gas chromatography coupled to a time-of-flight mass spectrometer were applied to identify novel contaminants in 40 pooled serum samples from a sub-population (n = 400) of the 2015–2017 national biomonitoring program. Suspect screening analysis was performed using an in-house library based on retention times and quantifier and qualifier ions for 222 contaminants, including persistent organic pollutants and emerging contaminants. Non-target analysis was performed by matching deconvoluted mass spectra to the spectral library from the National Institute of Standards and Technology. The suspect screening analysis identified organochlorinated pesticides, organophosphate esters, phthalate esters, and alternative plasticizers. Among the 68 compounds identified in the non-target analysis, siloxanes, novel organophosphate esters, and UV ink photoinitiators were considered candidates for future inclusion in the biomonitoring program based upon significant human exposure. Our findings demonstrate the feasibility of suspect and non-target analysis to identify novel contaminants to prioritize for inclusion within a national human biomonitoring program. © 2024 Elsevier Ltd

引用

共 86 条

[21]

Genuis S.J., Beesoon S., Lobo R.A., Birkholz D., Human elimination of phthalate compounds: blood, urine, and sweat (BUS) study, Sci. World, 615068, (2012)

[22]

Gil-Solsona R., Nika M.-C., Bustamante M., Villanueva C.M., Foraster M., Cosin-Tomas M., Alygizakis N., Gomez-Roig M.D., Llurba-Olive E., Sunyer J., Thomaidis N.S., Dadvand P., Gago-Ferrero P., The potential of sewage sludge to predict and evaluate the human chemical exposome, Environ. Sci. Technol. Lett., 8, pp. 1077-1084, (2021)

[23]

Grashow R., Bessonneau V., Gerona R.R., Wang A., Trowbridge J., Lin T., Buren H., Rudel R.A., Morello-Frosch R., Integrating exposure knowledge and serum suspect screening as a new approach to biomonitoring: an application in firefighters and office workers, Environ. Sci. Technol., 54, pp. 4344-4355, (2020)

[24]

Hanssen L., Warner N.A., Braathen T., Odland J.O., Lund E., Nieboer E., Sandanger T.M., Plasma concentrations of cyclic volatile methylsiloxanes (cVMS) in pregnant and postmenopausal Norwegian women and self-reported use of personal care products (PCPs), Environ. Int., 51, pp. 82-87, (2013)

[25]

He C., Toms L.M.L., Phong T., Van den Eede N., Wang X.Y., Li Y., Baduel C., Harden F.A., Heffernan A.L., Hobson P., Covaci A., Mueller J.F., Urinary metabolites of organophosphate esters: concentrations and age trends in Australian children, Environ. Int., 111, pp. 124-130, (2018)

[26]

He M.J., Lu J.F., Ma J.Y., Wang H., Du X.F., Organophosphate esters and phthalate esters in human hair from rural and urban areas, Chongqing, China: concentrations, composition profiles and sources in comparison to street dust, Environ. Pollut., 237, pp. 143-153, (2018)

[27]

Report on human biomonitoring of environmental chemicals in Canada – Results of the Canadian health measures survey Cycle 1 (2007–2009), pp. 1-292, (2010)

[28]

Hollerer C., Becker G., Goen T., Eckert E., Human metabolism and kinetics of tri-(2-ethylhexyl) trimellitate (TEHTM) after oral administration, Arch. Toxicol., 92, pp. 2793-2807, (2018)

[29]

Hou M.M., Shi Y.L., Jin Q., Cai Y.Q., Organophosphate esters and their metabolites in paired human whole blood, serum, and urine as biomarkers of exposure, Environ. Int., 139, (2020)

[30]

Hou R., Xu Y., Wang Z., Review of OPFRs in animals and humans: absorption, bioaccumulation, metabolism, and internal exposure research, Chemosphere, 153, pp. 78-90, (2016)

← 1 2 3 4 5 6 7 8 9 →