Nationwide human biomonitoring strategy in Korea: Prioritization of novel contaminants using GC/TOF-MS with suspect and non-target screening

被引：1
作者：
Mok, Sori [1 ]
Lee, Sunggyu [1 ]
Lee, Nahyun [2 ]
Kim, Sungkyoon [2 ]
Choi, Kyungho [2 ]
Park, Jeongim [3 ]
Kho, Younglim [4 ]
Moon, Hyo-Bang [1 ]
机构：
[1] Department of Marine Science and Convergence Technology, College of Science and Convergence Technology, Hanyang University, Ansan
[2] Graduate School of Public Health, Seoul National University, Seoul
[3] Department of Environmental Health Sciences, Soonchunhyang University, Asan
[4] Department of Health, Environment & Safety, Eulji University, Gyeonggi-do, Seongnam
来源：
Chemosphere | 2024年 / 369卷
关键词：
Emerging contaminants; Human biomonitoring; Plasticizers; Prioritization; TOF;
D O I：
10.1016/j.chemosphere.2024.143814
中图分类号：
学科分类号：
摘要：
According to global regulations on hazardous chemicals, numerous alternatives have been manufactured and used in various consumer products. Suspect and non-target analyses are advanced analytical techniques used for identifying novel contaminants. In the present study, suspect and non-target analytical approaches using a gas chromatography coupled to a time-of-flight mass spectrometer were applied to identify novel contaminants in 40 pooled serum samples from a sub-population (n = 400) of the 2015–2017 national biomonitoring program. Suspect screening analysis was performed using an in-house library based on retention times and quantifier and qualifier ions for 222 contaminants, including persistent organic pollutants and emerging contaminants. Non-target analysis was performed by matching deconvoluted mass spectra to the spectral library from the National Institute of Standards and Technology. The suspect screening analysis identified organochlorinated pesticides, organophosphate esters, phthalate esters, and alternative plasticizers. Among the 68 compounds identified in the non-target analysis, siloxanes, novel organophosphate esters, and UV ink photoinitiators were considered candidates for future inclusion in the biomonitoring program based upon significant human exposure. Our findings demonstrate the feasibility of suspect and non-target analysis to identify novel contaminants to prioritize for inclusion within a national human biomonitoring program. © 2024 Elsevier Ltd
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  • [1] Anderson W.A.C., Castle L., Hird S., Jeffery J., Scotter M.J., A twenty-volunteer study using deuterium labelling to determine the kinetics and fractional excretion of primary and secondary urinary metabolites of di-2-ethylhexylphthalate and di-iso-nonylphthalate, Food Chem. Toxicol., 49, pp. 2022-2029, (2011)
  • [2] Aparicio J.L., Elizalde M., Migration of photoinitiators in food packaging: a review, Packag. Technol. Sci., 28, pp. 181-203, (2015)
  • [3] Aznar M., Domeno C., Nerin C., Bosetti O., Set-off of non volatile compounds from printing inks in food packaging materials and the role of lacquers to avoid migration, Dyes Pigments, 114, pp. 85-92, (2015)
  • [4] Baduel C., Mueller J.F., Tsai H., Gomez-Ramos M.J., Development of sample extraction and clean-up strategies for target and non-target analysis of environmental contaminants in biological matrices, J. Chromatogr. A, 1426, pp. 33-47, (2015)
  • [5] Barmpas M., Vakonaki E., Tzatzarakis M., Sifakis S., Alegakis A., Grigoriadis T., Sodre B.D., Daskalakis G., Antsaklis A., Tsatsakis A., Organochlorine pollutants' levels in hair, amniotic fluid and serum samples of pregnant women in Greece. A cohort study, Environ. Toxicol. Pharmacol., 73, (2020)
  • [6] Bastiaensen M., Malarvannan G., Been F., Yin S., Yao Y., Huygh J., Clotman K., Schepens T., Jorens P.G., Covaci A., Metabolites of phosphate flame retardants and alternative plasticizers in urine from intensive care patients, Chemosphere, 233, pp. 590-596, (2019)
  • [7] Bastiaensen M., Malarvannan G., Gys C., Bamai Y.A., Araki A., Covaci A., Between- and within-individual variability of urinary phthalate and alternative plasticizer metabolites in spot, morning void and 24-h pooled urine samples, Environ. Res., 191, (2020)
  • [8] Bjerregaard-Olesen C., Long M., Ghisari M., Bech B.H., Nohr E.A., Uldbjerg N., Henriksen T.B., Olsen J., Bonefeld-Jorgensen E.C., Temporal trends of lipophilic persistent organic pollutants in serum from Danish nulliparous pregnant women 2011–2013, Environ. Sci. Pollut. Res., 24, pp. 16592-16609, (2017)
  • [9] Blum A., Behl M., Birnbaum L.S., Diamond M.L., Phillips A., Singla V., Sipes N.S., Stapleton H.M., Vinier M., Organophosphate flame retardants: are they a regrettable substitution for polybrominated diphenyl ethers?, Environ. Sci. Technol. Lett., 6, pp. 638-649, (2019)
  • [10] Fourth National Report on Human Exposure to Environmental Chemicals, (2009)
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