Natural compounds and derivatives as modulators of multidrug resistance and their mechanisms of action: recent studies in vitro, in vivo and in silico

被引：0
|
作者：
Sanchez-Carranza, Jessica Nayelli [1 ]
Montes-Helguera, Shawa Veronica [1 ]
Valladares-Mendez, Adriana [1 ]
Salas-Vidal, Enrique [2 ]
Gonzalez-Maya, Leticia [1 ]
机构：
[1] Univ Autonoma Estado Morelos, Fac Farm, Cuernavaca 62209, Morelos, Mexico
[2] Univ Nacl Autonoma Mexico, Dept Genet Desarrollo & Fisiol Mol, Inst Biotecnol, Cuernavaca 62209, Morelos, Mexico
来源：
DISCOVER APPLIED SCIENCES | 2024年 / 6卷 / 10期
关键词：
Multidrug resistance; Natural compounds; Chemotherapy; Chemosensitizing; P-gp; Flavonoids; Taxanes; JAK/STAT3; NF-kB; Cancer; P-GLYCOPROTEIN; BINDING; REVERSAL; FLAVONOIDS; TRANSPORT; BAICALEIN; SITES; DRUGS;
D O I：
10.1007/s42452-024-06239-9
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Drug resistance used in chemotherapy is a common challenge in cancer treatment. The present review of resistance-modulating molecules in cancer recapitulates in vitro, in vivo, and in silico studies of flavonoids, lactones, taxanes, curcuminoids, catechins, and chalcones stand out among others. The main mechanisms of action involve inhibiting the overexpression and function of efflux proteins and altering signaling pathways related to resistance. For their part, the discussed in silico studies identified key interactions between modulating molecules and multidrug resistance (MDR) transporters. This information supports research on synthetic modifications to create new scaffolds for reversing MDR and minimizing toxicity.
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页数：31
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