Metabolite Annotation through Stable Isotope Labeling

被引:0
|
作者
Dong, Yonghui [1 ,2 ]
Feldberg, Liron [3 ]
Aharoni, Asaph [4 ]
Heinig, Uwe [2 ]
机构
[1] Fujian Agr & Forestry Univ, Haixia Inst Sci & Technol, FAFU UCR Joint Ctr Hort Biol & Metabol, Fuzhou 350002, Peoples R China
[2] Weizmann Inst Sci, Life Sci Core Facil, Rehovot, Israel
[3] Israel Inst Biol Res, Dept Analyt Chem, Ness Ziona, Israel
[4] Weizmann Inst Sci, Dept Plant & Environm Sci, Rehovot, Israel
关键词
Stable isotope labeling; Mass spectrometry; Metabolomics; Metabolite annotation; SPECTROMETRY-BASED METABOLOMICS; MASS-SPECTROMETRY; GLOBAL TRACKING; PRODUCTS; FEATURES; SPACE; TOOLS; GUIDE; FLUX;
D O I
10.1016/j.trac.2024.118037
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Stable isotope labeling (SIL) is a powerful tool for probing cellular metabolism and has been increasingly employed for metabolite annotation in mass spectrometry-based metabolomics. Herein, we outline the principles and methods of designing and performing SIL-based experiments in metabolomics studies. Further, we summarize different SIL approaches and highlight recent examples of their use for metabolite annotation, including biological feature recognition, degenerate feature annotation, elemental composition determination and metabolite structure elucidation, across diverse biological systems. Throughout, the opportunities, open challenges, and potential pitfalls of each SIL workflow are discussed. Finally, we summarize and compare the recently developed software tools for the analysis of SIL-based metabolomics data.
引用
收藏
页数:10
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